38 Result(s)

Article

Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8⁺ T cell exhaustion

Tumor extracellular matrix has been associated with drug resistance and immune suppression. Here, proteomic and RNA profiling reveal increased collagen levels in lung tumors resistant to PD-1/PD-L1 blockade. A...

David H. Peng, Bertha Leticia Rodriguez, Lixia Diao, Limo Chen… in Nature Communications (2020)

Article

Comprehensive T cell repertoire characterization of non-small cell lung cancer

Immunotherapy targeting T cells is increasingly utilized to treat solid tumors including non-small cell lung cancer (NSCLC). This requires a better understanding of the T cells in the lungs of patients with NS...

Alexandre Reuben, Jiexin Zhang, Shin-Heng Chiou… in Nature Communications (2020)

Article

ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, due in part to the propensity of lung cancer to metastasize. Aberrant epithelial-to-mesenchymal transition (EMT) is a ...

Roxsan Manshouri, Etienne Coyaud, Samrat T. Kundu, David H. Peng… in Nature Communications (2019)

Article

A novel ex vivo tumor system identifies Src-mediated invasion and metastasis in mesenchymal tumor cells in non-small cell lung cancer

Lung cancer is the foremost cause of cancer related deaths in the U.S. It is a heterogeneous disease composed of genetically and phenotypically distinct tumor cells surrounded by heterotypic cells and extracel...

Aparna Padhye, Christin Ungewiss, Jared J. Fradette… in Scientific Reports (2019)

Article

TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins

Metastatic lung cancer is the leading cause of cancer-associated mortality worldwide, therefore necessitating novel approaches to identify specific genetic drivers for lung cancer progression and metastasis. W...

Samrat T. Kundu, Caitlin L. Grzeskowiak, Jared J. Fradette… in Nature Communications (2018)

Article

In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer

Genetic aberrations driving pro-oncogenic and pro-metastatic activity remain an elusive target in the quest of precision oncology. To identify such drivers, we use an animal model of KRAS-mutant lung adenocarcino...

Caitlin L. Grzeskowiak, Samrat T. Kundu, **ulei Mo… in Nature Communications (2018)

Article

Effect of neoadjuvant chemotherapy on the immune microenvironment in non–small cell lung carcinomas as determined by multiplex immunofluorescence and image analysis approaches

The clinical efficacy observed with inhibitors of programed cell death 1/programed cell death ligand 1 (PD-L1/PD-1) in cancer therapy has prompted studies to characterize the immune response in several tumor t...

Edwin R. Parra, Pamela Villalobos, Carmen Behrens… in Journal for ImmunoTherapy of Cancer (2018)

Article

Pan-urologic cancer genomic subtypes that transcend tissue of origin

Urologic cancers include cancers of the bladder, kidney, prostate, and testes, with common molecular features spanning different types. Here, we show that 1954 urologic cancers can be classified into nine majo...

Fengju Chen, Yiqun Zhang, Dominick Bossé, Aly-Khan A. Lalani… in Nature Communications (2017)

Article

Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set

While clinical outcomes following immunotherapy have shown an association with tumor mutation load using whole exome sequencing (WES), its clinical applicability is currently limited by cost and bioinformatics...

Jason Roszik, Lauren E. Haydu, Kenneth R. Hess, Junna Oba, Aron Y. Joon… in BMC Medicine (2016)

Article

A genetic cell context-dependent role for ZEB1 in lung cancer

The Zinc-finger E-box-binding Homeobox-1 (ZEB1) is a transcription factor that promotes epithelial–mesenchymal transition (EMT) and acts as an oncogene in KRAS-mutated lung cancer models. Here we report that ZEB1...

Ting Zhang, Lixia Guo, Chad J. Creighton, Qiang Lu, Don L. Gibbons… in Nature Communications (2016)

Article

The microRNA-200/Zeb1 axis regulates ECM-dependent β1-integrin/FAK signaling, cancer cell invasion and metastasis through CRKL

Tumor cell metastasis is a complex process that has been mechanistically linked to the epithelial-mesenchymal transition (EMT). The double-negative feedback loop between the microRNA-200 family and the Zeb1 tr...

Christin Ungewiss, Zain H. Rizvi, Jonathon D. Roybal, David H. Peng… in Scientific Reports (2016)

Chapter

Specific Roles for Lipids in Virus Fusion and Exit Examples from the Alphaviruses

Margaret Kielian, Prodyot K. Chatterjee… in Fusion of Biological Membranes and Related… (2002)