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  1. No Access

    Article

    Clinical patterns of metastasis

    In human solid cancer, lymph node status is the most important indicator for clinical outcome. Recent developments in the sentinel lymph node concept and technology have resulted in a more precise way of exami...

    Stanley P. L. Leong, Blake Cady, David M. Jablons… in Cancer and Metastasis Reviews (2006)

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    Article

    Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis

    The Wnt family of secreted glycoproteins is widely involved in cell proliferation, differentiation and oncogenesis. Many Wnt signaling genes are upregulated and activated in chronic lymphocytic leukemia. Less ...

    Julien Mazieres, Liang You, Biao He, Zhidong Xu, Amie Y Lee, Iwao Mikami… in Oncogene (2005)

  3. Article

    Open Access

    Efficacy of Wnt-1 monoclonal antibody in sarcoma cells

    Sarcomas are one of the most refractory diseases among malignant tumors. More effective therapies based on an increased understanding of the molecular biology of sarcomas are needed as current forms of therapy...

    Iwao Mikami, Liang You, Biao He, Zhidong Xu, Sonny Batra, Amie Y Lee… in BMC Cancer (2005)

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    Article

    Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations

    Aberrant Wnt signaling, mainly through mutations of APC and in some cases of CTNNB1 or AXIN2, has been found in the majority of colorectal cancers. Recently, frequent promoter hypermethylation was identified to c...

    Biao He, Noemi Reguart, Liang You, Julien Mazieres, Zhidong Xu, Amie Y Lee… in Oncogene (2005)

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    Article

    Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma

    Secreted frizzled-related proteins (sFRPs) comprise a family of five secreted glycoproteins that antagonize Wnt signaling. Aberrant activation and upregulation of the Wnt pathway is a key feature of many cance...

    Amie Y Lee, Biao He, Liang You, Sina Dadfarmay, Zhidong Xu, Julien Mazieres… in Oncogene (2004)

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    Article

    Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells

    In this report, we have demonstrated that Wnt-2 protein is overexpressed in freshly resected human non-small-cell lung cancer (NSCLC) tissues. We have also developed a monoclonal antibody against the N-terminu...

    Liang You, Biao He, Zhidong Xu, Kazutsugu Uematsu, Julien Mazieres, Iwao Mikami… in Oncogene (2004)

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    Protocol

    Matrix Metalloproteinase Expression in Lung Cancer

    The importance of matrix metalloproteinases (MMPs) in the growth and spread of solid tumors has been known for over a decade (1,2). However, the molecular mechanisms that regulate their expression and the elucida...

    Melissa Lim, David M. Jablons in Lung Cancer (2003)

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