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Article
Open AccessA protein kinase C α and β inhibitor blunts hyperphagia to halt renal function decline and reduces adiposity in a rat model of obesity-driven type 2 diabetes
Type 2 diabetes (T2D) and its complications can have debilitating, sometimes fatal consequences for afflicted individuals. The disease can be difficult to control, and therapeutic strategies to prevent T2D-ind...
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Article
Open AccessPan cancer characterization of genes whose expression has been associated with LINE-1 antisense promoter activity
Long interspersed nuclear element-1 (LINE-1 or L1) comprises 17% of the human genome. As the only autonomous and active retrotransposons, L1 may take part in cancer initiation and progression in some ways. The...
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Article
Open AccessThe external time-of-flight wall for CEE experiment
A heavy-ion collision facility called the cooler storage ring (CSR) external-target experiment (CEE) is scheduled in Lanzhou, China. The time measurement of the charged particles at the forward angle will be c...
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Article
Photodynamic therapy improves the outcome of immune checkpoint inhibitors via remodelling anti-tumour immunity in patients with gastric cancer
Photodynamic therapy (PDT) plays an immunoregulatory role in tumours. Here, we conducted a retrospective patient analysis to evaluate the effectiveness of PDT plus immune checkpoint inhibitors (ICIs) in gastri...
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Open AccessSleep quality in women with diabetes in pregnancy: a single-center retrospective study
Sleep quality is an important indicator of individual quality of life, which not only affects people’s mental health but is also closely related to the occurrence of many diseases. Sleep disorders associated w...
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Article
Study on the synergistic effect and mechanism of inhibitors benzotriazole and pyrazole on copper surface
In the giant large-scale integrated circuits manufacturing process, chemical mechanical polishing (CMP) for Cu interconnection can lead to chemical corrosion on Cu surface if inhibitors are not added to the CM...
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Article
Adaptive Statistical Spatial Downscaling of Precipitation Supported by High-Resolution Atmospheric Simulation Data for Mountainous Areas of Nepal
In complex terrain regions, it is very challenging to obtain high accuracy and resolution precipitation data that are required in land hydrological studies. In this study, an adaptive precipitation downscaling...
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Article
Open AccessEfficacy and safety of robot-assisted laparoscopic myomectomy versus laparoscopic myomectomy: a systematic evaluation and meta-analysis
Systematic evaluation of the efficacy and safety of robotic-assisted laparoscopic myomectomy (RALM) versus laparoscopic myomectomy (LM).
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Article
Open AccessParsing altered gray matter morphology of depression using a framework integrating the normative model and non-negative matrix factorization
The high inter-individual heterogeneity in individuals with depression limits neuroimaging studies with case-control approaches to identify promising biomarkers for individualized clinical decision-making. We ...
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Article
Open AccessLeveraging spatial transcriptomics data to recover cell locations in single-cell RNA-seq with CeLEry
Single-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of cellular heterogeneity in health and disease. However, the lack of physical relationships among dissociated cells has limited its ...
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Article
Open AccessGut microbiota signatures and fecal metabolites in postmenopausal women with osteoporosis
Women suffer from various distress and disturbances after menopause, including osteoporosis, a risk factor associated with multiple diseases. Altered gut microbiota has been implicated in postmenopausal osteop...
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Article
Advance in 3D self-supported amorphous nanomaterials for energy storage and conversion
The advancement of next-generation energy technologies calls for rationally designed and fabricated electrode materials that have desirable structures and satisfactory performance. Three-dimensional (3D) self-...
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Article
Open AccessHuman Amniotic Mesenchymal Stem Cells Alleviate aGVHD after allo-HSCT by Regulating Interactions between Gut Microbiota and Intestinal Immunity
Acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation poses one of the most vexing challenges. Gut microbiota dysbiosis can proceed aGVHD and mesenchymal stem cells (...
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Article
Cellulose derivatives functionalized with multidentate N‑donor atoms: comparative adsorption of cadmium (II) and lead (II) ions from water
Cellulose derivatives functionalized with multidentate N‑donor atoms containing two, three and four amino functional groups (as marked N2–CL, N3–CL and N4–CL) have been prepared by grafting of linear aliphatic po...
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Article
Editing of TOM1 gene in tobacco using CRISPR/Cas9 confers resistance to Tobacco mosaic virus
Genome editing technology has become one of the excellent tools for precise plant breeding to develop novel plant germplasm. The Tobacco mosaic virus (TMV) is the most prominent pathogen that infects several Sola...
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Article
A review on CRISPR/Cas: a versatile tool for cancer screening, diagnosis, and clinic treatment
Cancer is one of the leading causes of death worldwide and it has the trend of increase incidence. However, in the past decades, as quickly developed new technologies and modified old techniques for cancer scr...
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Article
The resilient cotton plant: uncovering the effects of stresses on secondary metabolomics and its underlying molecular mechanisms
Cotton is an important fiber crop cultivated around the world under diverse climate conditions and generates billions of dollars in annual revenue globally. Biotic and abiotic stresses have caused reduction in...
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Article
Open AccessscRNASequest: an ecosystem of scRNA-seq analysis, visualization, and publishing
Single-cell RNA sequencing is a state-of-the-art technology to understand gene expression in complex tissues. With the growing amount of data being generated, the standardization and automation of data analysi...
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Article
Insights to Gossypium defense response against Verticillium dahliae: the Cotton Cancer
The soil-borne pathogen Verticillium dahliae, also referred as “The Cotton Cancer,” is responsible for causing Verticillium wilt in cotton crops, a destructive disease with a global impact. To infect cotton plant...
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Associations Between the Lead Level in Maternal Blood and Umbilical Cord Blood and Congenital Heart Diseases in Offspring
The incidence of congenital heart diseases (CHDs) shows an increasing trend and results in large health burdens in China. However, there have been inconsistent results of the relationship between lead (Pb) lev...
