118 Result(s)

Article

Advances in the Mechanistic Study of the Control of Oxidative Stress Injury by Modulating HDAC6 Activity

Oxidative stress is defined as an injury resulting from a disturbance in the dynamic equilibrium of the redox environment due to the overproduction of active/radical oxygen exceeding the antioxidative ability ...

Yuanye Xue, Bing Gan, Yanxing Zhou, Tingyu Wang… in Cell Biochemistry and Biophysics (2023)

Article

Elevated fatty acid β-oxidation by leptin contributes to the proinflammatory characteristics of fibroblast-like synoviocytes from RA patients via LKB1-AMPK pathway

Fibroblast-like synoviocytes (FLS) maintain chronic inflammation leading to joint destruction in rheumatoid arthritis (RA). Fatty acid β-oxidation (FAO) regulates cell function. Here, we aimed to investigate t...

**g Wei, **nxin Huang, **ng Zhang, Guanghong Chen, Cheng Zhang… in Cell Death & Disease (2023)

Article

FcγRIIIA activation-mediated up-regulation of glycolysis alters MDSCs modulation in CD4⁺ T cell subsets of Sjögren syndrome

Our and other researchers’ previous studies found that myeloid-derived suppressor cells (MDSCs) were increased, and these MDSCs, supposed to play immunosuppressive roles, showed significant pro-inflammatory ef...

**g**g Qi, **nyang Zhou, Ziran Bai, Zhimin Lu, **aolu Zhu… in Cell Death & Disease (2023)

Article

Aspirin increases chemosensitivity of colorectal cancer cells and inhibits the expression of toll-like receptor 4

Chemotherapy resistance is an important bottleneck affecting the efficacy of chemotherapy in colon cancer. Therefore, improving the chemotherapy sensitivity of colorectal cancer cells is of great significance ...

Jun Ying, Haiyang Zhou, Zhiguo Wang, Qing You, Junnan Chen… in Cancer Cell International (2023)

Article

Correction to: MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening

Guangsuo **ng, Zichao Liu, Luyuan Huang, Danyun Zhao… in Cell Death & Differentiation (2022)

Article

Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling

SARS-CoV-2 vaccine booster dose can induce a robust humoral immune response, however, its cellular mechanisms remain elusive. Here, we investigated the durability of antibody responses and single-cell immune p...

**gwen Ai, **gxin Guo, Haocheng Zhang, Yi Zhang, Haochen Yang, Ke Lin… in Cell Discovery (2022)

Article

scMTD: a statistical multidimensional imputation method for single-cell RNA-seq data leveraging transcriptome dynamic information

Single-cell RNA sequencing (scRNA-seq) provides a powerful tool to capture transcriptomes at single-cell resolution. However, dropout events distort the gene expression levels and underlying biological signals...

**g Qi, Qiongyu Sheng, Yang Zhou, Jiao Hua, Shutong **ao, Shuilin ** in Cell & Bioscience (2022)

Article

Human adipose-derived mesenchymal stem cells-derived exosomes encapsulated in pluronic F127 hydrogel promote wound healing and regeneration

Large area skin trauma has always been a great challenge for both patients and clinicians. Exosomes originating from human adipose-derived mesenchymal stem cells (hADSCs) have been a novel promising cell-free ...

Yang Zhou, **ng-Liao Zhang, Shou-Tao Lu, Ning-Yan Zhang… in Stem Cell Research & Therapy (2022)

Article

Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy

In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors respond poorly or even not to IC...

Weitong Gao, Xueying Wang, Yang Zhou… in Signal Transduction and Targeted Therapy (2022)

Article

SIX5-activated LINC01468 promotes lung adenocarcinoma progression by recruiting SERBP1 to regulate SERPINE1 mRNA stability and recruiting USP5 to facilitate PAI1 protein deubiquitylation

Increasing research has uncovered the involvement of long noncoding RNAs (lncRNAs) in the progression of multiple cancers including lung adenocarcinoma (LUAD). RT-qPCR and western blot were done to measure RNA...

Yuan Yuan, Danyang Zhou, Feifei Chen, Zhenhua Yang, Wei Gu… in Cell Death & Disease (2022)

Article

Loss of neurodevelopmental-associated miR-592 impairs neurogenesis and causes social interaction deficits

microRNA-592 (miR-592) has been linked to neurogenesis, but the influence of miR-592 knockout in vivo remains unknown. Here, we report that miR-592 knockout represses IPC-to-mature neuron transition, impairs m...

Yu Fu, Yang Zhou, Yuan-Lin Zhang, Bo Zhao, … in Cell Death & Disease (2022)

Article

DNA methylation maintenance at the p53 locus initiates biliary-mediated liver regeneration

In cases of extensive liver injury, biliary epithelial cells (BECs) dedifferentiate into bipotential progenitor cells (BPPCs), then redifferentiate into hepatocytes and BECs to accomplish liver regeneration. W...

Jianbo He, Yang Zhou, Chuanfang Qian, Danyang Wang… in npj Regenerative Medicine (2022)

Article

Development of off-the-shelf hematopoietic stem cell-engineered invariant natural killer T cells for COVID-19 therapeutic intervention

New COVID-19 treatments are desperately needed as case numbers continue to rise and emergent strains threaten vaccine efficacy. Cell therapy has revolutionized cancer treatment and holds much promise in combat...

Yan-Ruide Li, Zachary Spencer Dunn, Gustavo Garcia Jr.… in Stem Cell Research & Therapy (2022)

Article

Neuronal GRK2 regulates microglial activation and contributes to electroacupuncture analgesia on inflammatory pain in mice

G protein coupled receptor kinase 2 (GRK2) has been demonstrated to play a crucial role in the development of chronic pain. Acupuncture is an alternative therapy widely used for pain management. In this study,...

Yu Chen, Yang Zhou, **ao-Chen Li, Xue Ma, Wen-Li Mi, Yu-**a Chu… in Biological Research (2022)

Article

Correction to: Mitochondrial gene expression analysis reveals aberrant transcription of cox3 in Gossypium barbadense CMS line H276A

Aziz Khan, **angjun Kong, **aofang Liao, Jie Zheng… in Development Genes and Evolution (2022)