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Article
Open AccessThe ELAVL3/MYCN positive feedback loop provides a therapeutic target for neuroendocrine prostate cancer
Neuroendocrine prostate cancer is a rapidly progressive and lethal disease characterized by early visceral metastasis, poor prognosis, and limited treatment options. Uncovering the oncogenic mechanisms could l...
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Article
Antimicrobial Peptides Targeting Streptococcus mutans: Current Research on Design, Screening and Efficacy
Antimicrobial peptides (AMPs) are small-molecule peptides that play a vital role in the nonspecific immune defense system of organisms. They mainly kill microorganisms by physically destroying the cell membran...
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Article
Open AccessQuantum storage of entangled photons at telecom wavelengths in a crystal
Quantum storage and distribution of entanglement are the key ingredients for realizing a global quantum internet. Compatible with existing fiber networks, telecom-wavelength entangled photons and corresponding...
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Article
Open AccessMetagenome-wide analysis uncovers gut microbial signatures and implicates taxon-specific functions in end-stage renal disease
The gut microbiota plays a crucial role in regulating host metabolism and producing uremic toxins in patients with end-stage renal disease (ESRD). Our objective is to advance toward a holistic understanding of...
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Article
Open AccessParticle flow simulation of Brazilian splitting failure characteristics of layered shale
Shale reservoir is the research hotspot in the development of unconventional oil and gas resources. The properties of bedding plane have an important influence on the mechanical behavior of shale. According to...
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Article
Open AccessRevealing the role of interfacial water and key intermediates at ruthenium surfaces in the alkaline hydrogen evolution reaction
Ruthenium exhibits comparable or even better alkaline hydrogen evolution reaction activity than platinum, however, the mechanistic aspects are yet to be settled, which are elucidated by combining in situ Raman...
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Article
Insights into the spectral property and electronic structure of di-triphenylaniline-modified monothiophene, dithiophene and thienothiophene
Density functional theory calculations at PBE38/6-311+G** level by involving the polarizable continuum model in solvent dichloromethane were employed to explore the geometries, electronic excitations and assoc...
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Article
Open AccessCarcinoma-associated fibroblast-derived lysyl oxidase-rich extracellular vesicles mediate collagen crosslinking and promote epithelial-mesenchymal transition via p-FAK/p-paxillin/YAP signaling
Carcinoma-associated fibroblasts (CAFs) are the main cellular components of the tumor microenvironment and promote cancer progression by modifying the extracellular matrix (ECM). The tumor-associated ECM is ch...
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Article
Enhanced performance of cesium copper halide nanocrystal light-emitting diodes via post-treatment induced phase regulation
Cesium copper halides have attracted increasing attention for light-emitting diodes (LEDs) applications due to their high photoluminescence quantum efficiency (PLQE) and non-toxicity. However, the current film...
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Article
Research Progress of spiking neural network in image classification: a review
Spiking neural network (SNN) is a new generation of artificial neural networks (ANNs), which is more analogous with the brain. It has been widely considered with neural computing and brain-like intelligence. S...
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Article
Open AccessContinuous venovenous hemodiafiltration versus standard medical therapy for the prevention of rhabdomyolysis-induced acute kidney injury: a retrospective cohort study
To determine whether continuous venovenous hemodiafiltration (CVVHDF) plus standard medical therapy (SMT) vs. SMT alone prevents rhabdomyolysis (RM)-induced acute kidney injury (AKI) and analyze the related he...
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Article
Dual-omics reveals temporal differences in acute sympathetic stress-induced cardiac inflammation following α1 and β-adrenergic receptors activation
Sympathetic stress is prevalent in cardiovascular diseases. Sympathetic overactivation under strong acute stresses triggers acute cardiovascular events including myocardial infarction (MI), sudden cardiac deat...
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Article
Research status and development of extraction process of zinc-bearing dust from ironmaking and steelmaking—a critical review
Almost 29.57–38.46 million tons of zinc-bearing dust were produced in Chinese iron and steel enterprises annually. The recovery of Zn and other metals in zinc-bearing dust from ironmaking and steelmaking could...
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Article
Review of available “extraction + purification” methods of natural ceramides and their feasibility for sewage sludge analysis
Natural ceramide, a biologically active compound present in plants, has been used widely in food, cosmetics, and pharmaceutical industries. Abundant ceramide has been detected in sewage sludge, which has inspi...
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Article
Open AccessA ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells
Internalization of complement membrane attack complexes (MACs) assembles NLRP3 inflammasomes in endothelial cells (EC) and promotes IL-β-mediated tissue inflammation. Informed by proteomics analyses of FACS-so...
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Article
Open AccessBiological evaluation of novel gemcitabine analog in patient-derived xenograft models of pancreatic cancer
Gemcitabine (Gem) has been a standard first-line drug for pancreatic cancer (PCa) treatment; however, Gem's rapid metabolism and systemic instability (short half-life) limit its clinical outcome. The objective...
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Article
Open AccessAdhesive cryogel particles for bridging confined and irregular tissue defects
Reconstruction of damaged tissues requires both surface hemostasis and tissue bridging. Tissues with damage resulting from physical trauma or surgical treatments may have arbitrary surface topographies, making...
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Article
Open AccessEvaluation of the immunization effectiveness of bOPV booster immunization and IPV revaccination
To provide a basis for further optimization of the polio sequential immunization schedule, this study evaluated the effectiveness of booster immunization with one dose of bivalent oral poliovirus vaccine (bOPV...
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Article
Paired quasi-periodic pulsations of hard X-ray emission in a solar flare
We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor (GECAM) during the flare event on 2022 April 21 at 01:52 UT. Several subpeaks...
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Article
Open AccessA TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2
The ideal vaccine against viruses such as influenza and SARS-CoV-2 must provide a robust, durable and broad immune protection against multiple viral variants. However, antibody responses to current vaccines of...
