208 Result(s)
within
**guang Chen
Life Sciences
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Article
Open AccessAn improved blood hemorrhaging treatment using diatoms frustules, by alternating Ca and light levels in cultures
Hemorrhage control requires hemostatic materials that are both effective and biocompatible. Among these, diatom biosilica (DBs) could significantly improve hemorrhage control, but it induces hemolysis (the hem...
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Open AccessCross-species single-cell transcriptomic analysis of animal gastric antrum reveals intense porcine mucosal immunity
As an important part of the stomach, gastric antrum secretes gastrin which can regulate acid secretion and gastric emptying. Although most cell types in the gastric antrum are identified, the comparison of cel...
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Article
Open AccessStandard: Human intestinal cancer organoids
Intestinal cancer is one of the most frequent and lethal types of cancer. Modeling intestinal cancer using organoids has emerged in the last decade. Human intestinal cancer organoids are physiologically releva...
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Article
Open AccessA type II protein arginine methyltransferase regulates merozoite invasion in Plasmodium falciparum
Protein arginine methyltransferases (PRMTs) regulate many important cellular processes, such as transcription and RNA processing in model organisms but their functions in human malaria parasites are not elucid...
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Open AccessRNF128 regulates neutrophil infiltration and myeloperoxidase functions to prevent acute lung injury
Acute lung injury (ALI) is characterised by severe pulmonary inflammation, alveolar-capillary barrier disruption, and pulmonary oedema. Therefore, establishing effective therapeutic targets for ALI prevention ...
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Article
Open AccessStandard: Human intestinal organoids
Organoids have attracted great interest for disease modelling, drug discovery and development, and tissue growth and homeostasis investigations. However, lack of standards for quality control has become a prom...
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Open AccessCRISPR/Cas9-mediated F1534S substitution in the voltage-gated sodium channel reveals its necessity and sufficiency for deltamethrin resistance in Aedes albopictus
Insecticide resistance in Aedes mosquitoes presents a major challenge to the control of arboviral diseases. However, resistance mechanisms for many of the insecticides remain unknown. A commonly used insecticide,...
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Effect of straw return with nitrogen fertilizer on photosynthetic characteristics and yield of rice in soda saline–alkali rice paddy fields
Many studies have shown that straw return to the field can promote the production of photosynthetic material for crops, and thus increase crop yields. Due to the different effects of straw return to the field ...
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Open AccessCombination treatment with FAAH inhibitors/URB597 and ferroptosis inducers significantly decreases the growth and metastasis of renal cell carcinoma cells via the PI3K-AKT signaling pathway
Ferroptosis, a nonapoptotic form of programmed cell death characterized by significant iron-dependent peroxidation of phospholipids, is regulated by cellular metabolism, redox homeostasis, and various cancer-r...
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Article
Open AccessPLK1 inhibition promotes apoptosis and DNA damage in glioma stem cells by regulating the nuclear translocation of YBX1
Glioma stem cells (GSCs) are the important cause of tumorigenesis, recurrence, and chemo(radio)resistance in glioma. Targeting GSCs helps improve the outcomes of glioma treatment. Polo-like kinase 1 (PLK1) is ...
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Open AccessDevelopment of a 32-gene signature using machine learning for accurate prediction of inflammatory bowel disease
Inflammatory bowel disease (IBD) is a chronic inflammatory condition caused by multiple genetic and environmental factors. Numerous genes are implicated in the etiology of IBD, but the diagnosis of IBD is chal...
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High-Throughput IgG Reformatting and Expression Using Hybrid Secretion Signals and InTag Positive Selection Technology
We have previously published protocols for high-throughput IgG reformatting and expression, that enable rapid reformatting of phage-displayed antibody Fab fragments into a single dual expression vector for ful...
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Article
Mechanism of molecules crosstalk and the critical role of jasmonic acid on triterpenoid synthesis in Cyclocarya Paliurus cells under Aspergillus niger elicitor
Cyclocarya paliurus (C. paliurus) leaves contain multiple health beneficial metabolites, and therefore are often used in functional foods and Chinese herbal medicines. However, breeding difficulties confines its ...
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Article
NDR1/HIN1-like genes may regulate Glycine max seed germination under chilling stress through the ABA pathway
NDR1/HIN1-like (NHL) genes play essential roles in triggering plant defenses in response to environmental stimuli. In the present study, we performed comprehensive identification, characterization, and transcript...
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Article
An inhibitory effect of schisandrone on α-hemolysin expression to combat methicillin-resistant staphylococcus aureus infections
Due to increasing antibiotic resistance, targeting bacterial virulence factors is now gaining further interest as an alternative strategy to develop novel classes of anti-infective agents. The critical role of...
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Article
Molecular response and evolution of plant anion transport systems to abiotic stress
We propose that anion channels are essential players for green plants to respond and adapt to the abiotic stresses associated changing climate via reviewing the literature and analyzing the molecular evolution...
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Open AccessDynamic genome evolution in a model fern
The large size and complexity of most fern genomes have hampered efforts to elucidate fundamental aspects of fern biology and land plant evolution through genome-enabled research. Here we present a chromosomal...
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Open AccessIntestinal cellular heterogeneity and disease development revealed by single-cell technology
The intestinal epithelium is responsible for food digestion and nutrient absorption and plays a critical role in hormone secretion, microorganism defense, and immune response. These functions depend on the int...
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Article
Open AccessInhibitory effect of the novel tyrosine kinase inhibitor DCC-2036 on triple-negative breast cancer stem cells through AXL-KLF5 positive feedback loop
Triple-negative breast cancer (TNBC), an aggressive histological subtype of breast cancer, exhibits a high risk of early recurrence rate and a poor prognosis, and it is primarily associated with the abundance ...
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Article
Halomonas faecis sp. nov., a halophilic bacterium isolated from human faeces
A novel moderately halophilic, Gram-stain-negative, catalase- and oxidase-positive, strictly aerobic, non-sporulating, non-motile rod, designated strain JSM 104105 T, was isolated from human faeces. Strain JSM 10...
