133 Result(s)
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Open AccessPreventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2
Effective drugs with broad spectrum safety profile to all people are highly expected to combat COVID-19 caused by SARS-CoV-2. Here we report that nelfinavir, an FDA approved drug for the treatment of HIV infec...
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Open AccessGut microbiota composition can reflect immune responses of latent tuberculosis infection in patients with poorly controlled diabetes
Diabetes mellitus (DM) is a major risk factor for tuberculosis (TB). Evidence has linked the DM-related dysbiosis of gut microbiota to modifiable host immunity to Mycobacterium tuberculosis infection. However, th...
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Open AccessThe causal relationship between white blood cell counts and hepatocellular carcinoma: a Mendelian randomization study
Most of hepatocellular carcinoma (HCC) arises on the background of chronic inflammation. The presence of infiltrating inflammatory cells is associated with tumour initiation, progression and clinical response ...
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Clinicopathological characteristics and prognostic factors of elderly small intestine adenocarcinoma using propensity score matching analysis: a study based on SEER database
Small intestine adenocarcinoma (SIA) is a scant disease that has no adequate clinical trials, so its prognostic factors are still unclear, especially in elderly patients. In this article, we aimed to explore t...
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Social isolation reinforces aging-related behavioral inflexibility by promoting neuronal necroptosis in basolateral amygdala
Aging is characterized with a progressive decline in many cognitive functions, including behavioral flexibility, an important ability to respond appropriately to changing environmental contingencies. However, ...
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Open AccessInduction immune-checkpoint inhibitors for resectable oncogene-mutant NSCLC: A multicenter pooled analysis
Despite limited efficacy of immunotherapy for advanced non-small-cell lung cancer (NSCLC) with driver mutations, whether neoadjuvant immunotherapy could be clinically valuable in those patients warrants furthe...
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Open AccessIL-37 protects against airway remodeling by reversing bronchial epithelial–mesenchymal transition via IL-24 signaling pathway in chronic asthma
Epithelial–mesenchymal transition (EMT) is one of the mechanisms of airway remodeling in chronic asthma. Interleukin (IL)-24 has been implicated in the promotion of tissue fibrosis, and increased IL-24 levels ...
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Open AccessResearch on the frailty status and adverse outcomes of elderly patients with multimorbidity
As patients age, the frailty of those with multimorbidity increases, often resulting in adverse health outcomes. The current study investigated the frailty status and the factors which influence it in elderly ...
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Open AccessIdentification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA
Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions of people in develo** countries. In the history of anti-malaria campaign, chloroquine (CQ) has played an indi...
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Galectin-1 orchestrates an inflammatory tumor-stroma crosstalk in hepatoma by enhancing TNFR1 protein stability and signaling in carcinoma-associated fibroblasts
Most cases of hepatocellular carcinoma (HCC) arise with the fibrotic microenvironment where hepatic stellate cells (HSCs) and carcinoma-associated fibroblasts (CAFs) are critical components in HCC progression....
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CT-guided transthoracic pulmonary artery catheterization: an experimental study in a porcine model
We investigated the safety and feasibility of CT-guided transthoracic pulmonary artery catheterization (TPAC) in a porcine model.
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Comparison of Silicosis and Tuberculosis Involving Mediastinal Lymph Nodes Based on Contrast-Enhanced Multidetector-Row Computed Tomography
To investigate the different imaging features of contrast-enhanced multidetector-row-computed tomography (MDCT) for distinguishing between silicosis and tuberculosis involving the mediastinal lymph nodes.
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Open AccessRNF144A exerts tumor suppressor function in breast cancer through targeting YY1 for proteasomal degradation to downregulate GMFG expression
Ring finger protein 144A (RNF144A), a poorly characterized member of the RING-in-between-RING family of E3 ubiquitin ligases, is an emerging tumor suppressor, but its underlying mechanism remains largely elusi...
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Shenqi Fuzheng Injection (参芪扶**注射液) Combined with Chemotherapy for Acute Leukemia: A Meta-Analysis
To evaluate to the efficacy and safety of Shenqi Fuzheng Injection (参芪扶**注射液, SFI) combined with chemotherapy in the treatment of acute leukemia (AL) by meta-analysis.
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Open AccessSix-month follow-up of functional status in discharged patients with coronavirus disease 2019
The long-term functional outcome of discharged patients with coronavirus disease 2019 (COVID-19) remains unresolved. We aimed to describe a 6-month follow-up of functional status of COVID-19 survivors.
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Application of topical gentamicin—a new era in the treatment of genodermatosis
The clinical use of gentamicin always lies in its antimicrobial activity in the past as an aminoglycoside antibiotic. However, in the past decade, there were considerable interests in therapeutic approaches in...
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FMR1 allele frequencies in 51,000 newborns: a large-scale population study in China
Fragile X syndrome (FXS), caused by CGG-repeat expansion in FMR1 promoter, is one of the most common causes of mental retardation. Individuals with full mutation and premutation alleles have a high risk of psycho...
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Open AccessOptimized Propofol Anesthesia Increases Power of Subthalamic Neuronal Activity in Patients with Parkinson’s Disease Undergoing Deep Brain Stimulation
Propofol is a general anesthetic option for deep brain stimulation (DBS) of the subthalamic nucleus (STN) of patients with Parkinson's disease (PD). However, its effects on STN activity and neuropsychological ...
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Disrupted Brain Network Topology in Drug-naïve Essential Tremor Patients with and Without Depression
This study was carried out to investigate brain functional connectome and its potential relationships with the disease severity and emotion function in patients with essential tremor with and without depressiv...
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A prognostic survival model based on metabolism-related gene expression in plasma cell myeloma
Accurate survival prediction of persons with plasma cell myeloma (PCM) is challenging. We interrogated clinical and laboratory co-variates and RNA matrices of 1040 subjects with PCM from public datasets in the...
