335 Result(s)
within
English
**ang-Liang Chen
Life Sciences
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Article
Open AccessDistribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery
Extant life depends greatly on the binding of small molecules (such as ligands) with macromolecules (such as proteins), and one ligand can bind multiple proteins. However, little is known about the global patt...
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Expression of a truncated ripening inhibitor (RIN) protein from tomato and production of an anti-RIN antibody
The tomato ripening mutant, ripening inhibitor (rin), whose fruits fails to ripen, has been identified and widely studied. The RIN gene has been cloned. Here we present the expression of a truncated form of the R...
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Species-dependent responses of juniper and spruce to increasing CO2 concentration and to climate in semi-arid and arid areas of northwestern China
Qilian juniper (Sabina przewalskii Kom.) and Qinghai spruce (Picea crassifolia Kom.) represent different tree functional types, which can be found extensively in northwestern China. The former is drought-tolerant...
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Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells
Since Notch signaling plays a critical role in stem cells and oncogenesis, we hypothesized that Notch signaling might play roles in cancer stem cells and cancer cells with a stem cell phenotype. In this study,...
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Open AccessAltered expression patterns of lipid metabolism genes in an animal model of HCV core-related, nonobese, modest hepatic steatosis
Because the gene expression patterns of nonobese hepatic steatosis in affected patients remain unclear, we sought to explore these patterns using an animal model of nonobese hepatic steatosis.
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Polymorphisms of the uridine-diphosphoglucuronosyltransferase 1A1 gene and coronary artery disease
Bilirubin, an antioxidant in the blood, plays a role in protection from atherosclerosis. The level of bilirubin is highly correlated to the incidence of coronary artery disease (CAD). Unconjugated bilirubin is...
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Article
Salinicoccus salitudinis sp. nov., a new moderately halophilic bacterium isolated from a saline soil sample
A novel pale-yellow-pigmented, moderately halophilic, facultatively alkaliphilic, non-motile, non-spore-forming, catalase- and oxidase-positive, obligately aerobic Gram-positive coccus, strain YIM-C678T was isola...
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Threatened fishes of the world: Tanichthys albonubes Lin 1932 (Cyprinidae)
The white cloud mountain minnow Tanichthys albonubes Lin is an endemic species to southern China and the genus has two species, Tanichthys albonubes Lin and Tanichthys micagemmae Freyhof et Herder. The distributi...
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Open AccessConstruction of a cancer-perturbed protein-protein interaction network for discovery of apoptosis drug targets
Cancer is caused by genetic abnormalities, such as mutations of oncogenes or tumor suppressor genes, which alter downstream signal transduction pathways and protein-protein interactions. Comparisons of the int...
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TLR-independent induction of human monocyte IL-1 by phosphoglycolipids from thermophilic bacteria
The structures of phosphoglycolipids PGL1 and PGL2 from the thermophilic bacteria Meiothermus taiwanensis, Meiothermus ruber, Thermus thermophilus, and Thermus oshimai are determined recently (Yang et al. in J Li...
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Development and characterization of microsatellite loci for lotus (Nelumbo nucifera)
This paper reports the development of microsatellite primers for Nelumbo nucifera Gaerten. By screening genomic libraries enriched with 10 kinds of probes, Seventeen polymorphic loci were isolated and primers wer...
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Article
Halomonas sediminis sp. nov., a new halophilic bacterium isolated from salt-lake sediment in China
A novel Gram-negative, slightly halophilic, catalase- and oxidase-positive, obligately aerobic bacterium, strain YIM-C248T, was isolated from a sediment sample collected from a salt-lake in the Qaidam Basin in Qi...
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Adventitious bud regeneration from leaf explants of Platanus occidentalis L. and genetic stability assessment
The aim of this work is to develop a method of plant regeneration from leaf explants of Platanus occidentalis L. successfully. Woody plant medium (HortScience 16:453–459, 1981) and Murashige and Skoog (Physiol Pl...
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Differential Expression of Serine/Threonine Protein Phosphatase Type-2C Under Drought Stress in Maize
Differential display reverse transcription polymerase chain reaction was used to study the messenger RNA differential expression of a drought tolerant inbred line ‘81565’ under drought stress and well-watered ...
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Article
Open AccessEmodin targets the β-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterization
The natural product Emodin demonstrates a wide range of pharmacological properties including anticancer, anti-inflammatory, antiproliferation, vasorelaxant and anti-H. pylori activities. Although its H. pylori in...
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Article
Open AccessStructural insights into the substrate tunnel of Saccharomyces cerevisiae carbonic anhydrase Nce103
The carbonic anhydrases (CAs) are involved in inorganic carbon utilization. They have been classified into six evolutionary and structural families: α-, β-, γ-, δ-, ε-, ζ- CAs, with β-CAs present in higher pla...
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Open AccessSnoRNAs from the filamentous fungus Neurospora crassa: structural, functional and evolutionary insights
SnoRNAs represent an excellent model for studying the structural and functional evolution of small non-coding RNAs involved in the post-transcriptional modification machinery for rRNAs and snRNAs in eukaryotic...
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Construction of Cancer-Perturbed Protein–Protein Interaction Network of Apoptosis for Drug Target Discovery
Inspecting interactive behaviors of proteins in cancer cells and comparing them with those in normal cells to obtain cancer-perturbed protein network can shed light on how a normal cell transforms into a cance...
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Article
Comparative performance of species-richness estimators using data from a subtropical forest tree community
We used survey data collected from a large plot (20 ha) of sub-tropical forest in the Dinghushan Nature Reserve, Guangdong Province, southern China, in 2005 to test the comparative performance of nine species-...
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Molecular cloning and characterization of a bifunctional xylanolytic enzyme from Neocallimastix patriciarum
A cDNA encoding a bifunctional acetylxylan esterase/xylanase, XynS20E, was cloned from the ruminal fungus Neocallimastix patriciarum. A putative conserved domain of carbohydrate esterase family 1 was observed at ...
