401 Result(s)

Article

Deficiency of skeletal muscle Agrin contributes to the pathogenesis of age-related sarcopenia in mice

Sarcopenia, a progressive and prevalent neuromuscular disorder, is characterized by age-related muscle wasting and weakening. Despite its widespread occurrence, the molecular underpinnings of this disease rema...

Jie Chen, Hong Chen, **a Dong, Tiankun Hui, Min Yan, Dongyan Ren… in Cell Death & Disease (2024)

Article

Tektin bundle interacting protein, TEKTIP1, functions to stabilize the tektin bundle and axoneme in mouse sperm flagella

Tektins are microtubule inner proteins (MIPs) and localize at the inside lumen of doublet microtubules (DMTs) of cilia/flagella. TEKTIP1, a newly identified protein by cryo-electron microscopy (cryo-EM), is pr...

**n-Yan Geng, Hui-Juan **, Lan **a, Bin-Bin Wang… in Cellular and Molecular Life Sciences (2024)

Article

The m⁶A reader IGF2BP2 regulates glycolytic metabolism and mediates histone lactylation to enhance hepatic stellate cell activation and liver fibrosis

Evidence for the involvement of N⁶-Methyladenosine (m⁶A) modification in the etiology and progression of liver fibrosis has emerged and holds promise as a therapeutic target. Insulin-like growth factor 2 (IGF2) m...

Yongqiang Zhou, Jiexi Yan, He Huang, Lu Liu, Longfei Ren… in Cell Death & Disease (2024)

Article

Molecular mechanism underlying miR-204-5p regulation of adipose-derived stem cells differentiation into cells from three germ layers

The limited differentiation ability of adipose-derived stem cells (ADSCs) limits their application in stem cell therapy and regenerative medicine. Here, we explore the molecular mechanism by which miR-204-5p r...

Zhimin Wang, Meiyu Bi, **aoshu Zhe, **ao Wang, Bai Dai, **aoyu Han… in Cell Death Discovery (2024)

Article

Endoplasmic reticulum stress and the unfolded protein response: emerging regulators in progression of traumatic brain injury

Traumatic brain injury (TBI) is a common trauma with high mortality and disability rates worldwide. However, the current management of this disease is still unsatisfactory. Therefore, it is necessary to invest...

Yayi Yang, Dengfeng Lu, Menghan Wang, Guangjie Liu, Yun Feng… in Cell Death & Disease (2024)

Article

Cardiac cell senescence: molecular mechanisms, key proteins and therapeutic targets

Cardiac aging, particularly cardiac cell senescence, is a natural process that occurs as we age. Heart function gradually declines in old age, leading to continuous heart failure, even in people without a prio...

Yi Luan, **aofan Zhu, Yuxue Jiao, Hui Liu, Zhen Huang, **yan Pei… in Cell Death Discovery (2024)

Article

Dysregulated palmitic acid metabolism promotes the formation of renal calcium-oxalate stones through ferroptosis induced by polyunsaturated fatty acids/phosphatidic acid

The pathogenesis of renal calcium-oxalate (CaOx) stones is complex and influenced by various metabolic factors. In parallel, palmitic acid (PA) has been identified as an upregulated lipid metabolite in the uri...

Rui Wang, **gdong Zhang, Haotian Ren, Shiyong Qi… in Cellular and Molecular Life Sciences (2024)

Article

Increased thrombospondin-1 levels contribute to epileptic susceptibility in neonatal hyperthermia without seizures via altered synaptogenesis

Childhood febrile seizures (FS) represent one of the most common types of seizures and may lead to severe neurological damage and an increased risk of epilepsy. However, most children with fevers do not show c...

Yujie Zhai, Yao Cheng, Yi Yuan, **anfeng Meng, Yang Li, Yan Wang… in Cell Death Discovery (2024)

Article

GITRL impairs hepatocyte repopulation by liver progenitor cells to aggravate inflammation and fibrosis by GITR⁺CD8⁺ T lymphocytes in CDE Mice

As an alternative pathway for liver regeneration, liver progenitor cells and their derived ductular reaction cells increase during the progression of many chronic liver diseases. However, the mechanism underly...

Li Li, Yu He, Kai Liu, Lin Liu, Shan Shan, Helin Liu, Jiangbo Ren… in Cell Death & Disease (2024)

Article

Vascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia

Vascular smooth muscle cell (VSMC) proliferation is the leading cause of vascular stenosis or restenosis. Therefore, investigating the molecular mechanisms and pivotal regulators of the proliferative VSMC phen...

Chao Su, Mingxia Liu, Xuyang Yao, Wei Hao… in Cellular and Molecular Life Sciences (2024)

Article

CHEK2 knockout is a therapeutic target for TP53-mutated hepatocellular carcinoma

Currently, there is still a lack of novel and effective drug targets to improve the prognosis of hepatocellular carcinoma (HCC). Additionally, the role of CHEK2 in HCC has not been reported yet. The eQTLgen da...

Yuyan Chen, Zhengyi Zhu, **ngyu Wu, Hui Li, Wenxian Guan… in Cell Death Discovery (2024)

Article

Targeting PAK4 reverses cisplatin resistance in NSCLC by modulating ER stress

Chemoresistance poses a significant impediment to effective treatments for non-small-cell lung cancer (NSCLC). P21-activated kinase 4 (PAK4) has been implicated in NSCLC progression by invasion and migration. ...

Shixin Liu, **shan Yang, Lu Wang, **aofang Zou, Dongdong Zhang… in Cell Death Discovery (2024)

Article

FKBP10 promotes clear cell renal cell carcinoma progression and regulates sensitivity to the HIF2α blockade by facilitating LDHA phosphorylation

Renal cell carcinoma (RCC) is one of the three major malignant tumors of the urinary system and originates from proximal tubular epithelial cells. Clear cell renal cell carcinoma (ccRCC) accounts for approxima...

Ren Liu, Zhihao Zou, Lingwu Chen, Yuanfa Feng, Jianheng Ye… in Cell Death & Disease (2024)

Article

Chimeric antigen receptor-based natural killer cell immunotherapy in cancer: from bench to bedside

Immunotherapy has rapidly evolved in the past decades in the battle against cancer. Chimeric antigen receptor (CAR)-engineered T cells have demonstrated significant success in certain hematologic malignancies,...

Beibei Zhang, Mengzhe Yang, Weiming Zhang, Ning Liu, Daogang Wang… in Cell Death & Disease (2024)

Article

Mitochondrial oxidative damage reprograms lipid metabolism of renal tubular epithelial cells in the diabetic kidney

The functional and structural changes in the proximal tubule play an important role in the occurrence and development of diabetic kidney disease (DKD). Diabetes-induced metabolic changes, including lipid metab...

Yanjuan Hou, Enxue Tan, Honghong Shi, **ayu Ren… in Cellular and Molecular Life Sciences (2024)

Article

Serine to proline mutation at position 341 of MYOC impairs trabecular meshwork function by causing autophagy deregulation

Glaucoma is a highly heritable disease, and myocilin was the first identified causal and most common pathogenic gene in glaucoma. Serine-to-proline mutation at position 341 of myocilin (MYOC^S341P) is associated w...

Xue**g Yan, Shen Wu, Qian Liu, Ying Cheng, Yufei Teng, Tianmin Ren… in Cell Death Discovery (2024)

Article

Upregulation of Hsp27 via further inhibition of histone H2A ubiquitination confers protection against myocardial ischemia/reperfusion injury by promoting glycolysis and enhancing mitochondrial function

Research suggests that ischemic glycolysis improves myocardial tolerance to anoxia and low-flow ischemia. The rate of glycolysis during ischemia reflects the severity of the injury caused by ischemia and subse...

Pilong Shi, Jiawei Wu, Minghui Li, Yonggang Cao, Jiabi Wu, ** Ren… in Cell Death Discovery (2023)

Article

Correction: In vitro CRISPR screening uncovers CRTC3 as a regulator of IFN-γ-induced ferroptosis of hepatocellular carcinoma

Li Li, Tao **ng, Yiran Chen, Weiran Xu, Bo Fan, Gaoda Ju, **g Zhao… in Cell Death Discovery (2023)

Article

A novel microtubule inhibitor promotes tumor ferroptosis by attenuating SLC7A11/GPX4 signaling

MP-HJ-1b is a novel microtubule inhibitor that we designed and reported previously. Ferroptosis is a newly identified type of nonapoptotic cell death induced by ferrous catalysis and lipid peroxidation. Here, ...

Nannan Ning, Ziqi Shang, Zhi** Liu, Zhizhou **a, Yang Li… in Cell Death Discovery (2023)

Article

m6A and m5C modification of GPX4 facilitates anticancer immunity via STING activation

Cancer immunotherapy is arguably the most rapidly advancing realm of cancer treatment. Glutathione peroxidase 4 (GPX4) has emerged as the vital enzyme to prevent lipid peroxidation and maintain cellular redox ...

Baoxiang Chen, Yuntian Hong, **ang Zhai, Yanrong Deng, Heng Hu… in Cell Death & Disease (2023)