477 Result(s)

Article

Blocking CIRP protects against acute pancreatitis by improving mitochondrial function and suppressing pyroptosis in acinar cells

Acute pancreatitis (AP) continues to pose a major challenge as targeted therapeutic interventions are absent. Mitochondrial dysfunction and inflammasome-dependent pyroptosis are involved in the pathogenic mech...

Wuming Liu, Yifan Ren, Tao Wang, Mengzhou Wang, Yujia Xu, Jia Zhang… in Cell Death Discovery (2024)

Article

Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer

Ferroptosis, a therapeutic strategy for tumours, is a regulated cell death characterised by the increased accumulation of iron-dependent lipid peroxides (LPO). Tumour-associated long non-coding RNAs (lncRNAs),...

Shasha **ang, Wen Yan, **ng Ren, Jianbo Feng… in Cellular & Molecular Biology Letters (2024)

Article

RIPK1 inhibitor ameliorates pulmonary injury by modulating the function of neutrophils and vascular endothelial cells

Acute lung injury (ALI) is an acute and progressive hypoxic respiratory failure that could progress to acute respiratory distress syndrome (ARDS) with a high mortality rate, thus immediate medical attention an...

Tao Yang, Cai-gui **ang, **ao-han Wang, Qing-qing Li, Shu-yue Lei… in Cell Death Discovery (2024)

Article

Mitochondria-associated endoplasmic reticulum membrane (MAM): a dark horse for diabetic cardiomyopathy treatment

Diabetic cardiomyopathy (DCM), an important complication of diabetes mellitus (DM), is one of the most serious chronic heart diseases and has become a major cause of heart failure worldwide. At present, the pa...

Yong Liu, **-Ling Huo, Kaidi Ren, Shaokang Pan, Hengdao Liu… in Cell Death Discovery (2024)

Article

Inhibition of EHMT1/2 rescues synaptic damage and motor impairment in a PD mouse model

Epigenetic dysregulation that leads to alterations in gene expression and is suggested to be one of the key pathophysiological factors of Parkinson’s disease (PD). Here, we found that α-synuclein preformed fib...

Zhixiong Zhang, Rui Wang, Hui Zhou, Dan Wu… in Cellular and Molecular Life Sciences (2024)

Article

Deficiency of skeletal muscle Agrin contributes to the pathogenesis of age-related sarcopenia in mice

Sarcopenia, a progressive and prevalent neuromuscular disorder, is characterized by age-related muscle wasting and weakening. Despite its widespread occurrence, the molecular underpinnings of this disease rema...

Jie Chen, Hong Chen, **a Dong, Tiankun Hui, Min Yan, Dongyan Ren… in Cell Death & Disease (2024)

Article

Tektin bundle interacting protein, TEKTIP1, functions to stabilize the tektin bundle and axoneme in mouse sperm flagella

Tektins are microtubule inner proteins (MIPs) and localize at the inside lumen of doublet microtubules (DMTs) of cilia/flagella. TEKTIP1, a newly identified protein by cryo-electron microscopy (cryo-EM), is pr...

**n-Yan Geng, Hui-Juan **, Lan **a, Bin-Bin Wang… in Cellular and Molecular Life Sciences (2024)

Article

The m⁶A reader IGF2BP2 regulates glycolytic metabolism and mediates histone lactylation to enhance hepatic stellate cell activation and liver fibrosis

Evidence for the involvement of N⁶-Methyladenosine (m⁶A) modification in the etiology and progression of liver fibrosis has emerged and holds promise as a therapeutic target. Insulin-like growth factor 2 (IGF2) m...

Yongqiang Zhou, Jiexi Yan, He Huang, Lu Liu, Longfei Ren… in Cell Death & Disease (2024)

Article

Retraction Note: A water-soluble DsbB variant that catalyzes disulfide-bond formation in vivo

Dario Mizrachi, Michael-Paul Robinson, Guo** Ren, Na Ke… in Nature Chemical Biology (2024)

Article

Molecular mechanism underlying miR-204-5p regulation of adipose-derived stem cells differentiation into cells from three germ layers

The limited differentiation ability of adipose-derived stem cells (ADSCs) limits their application in stem cell therapy and regenerative medicine. Here, we explore the molecular mechanism by which miR-204-5p r...

Zhimin Wang, Meiyu Bi, **aoshu Zhe, **ao Wang, Bai Dai, **aoyu Han… in Cell Death Discovery (2024)

Article

Endoplasmic reticulum stress and the unfolded protein response: emerging regulators in progression of traumatic brain injury

Traumatic brain injury (TBI) is a common trauma with high mortality and disability rates worldwide. However, the current management of this disease is still unsatisfactory. Therefore, it is necessary to invest...

Yayi Yang, Dengfeng Lu, Menghan Wang, Guangjie Liu, Yun Feng… in Cell Death & Disease (2024)

Article

Cardiac cell senescence: molecular mechanisms, key proteins and therapeutic targets

Cardiac aging, particularly cardiac cell senescence, is a natural process that occurs as we age. Heart function gradually declines in old age, leading to continuous heart failure, even in people without a prio...

Yi Luan, **aofan Zhu, Yuxue Jiao, Hui Liu, Zhen Huang, **yan Pei… in Cell Death Discovery (2024)

Article

Dysregulated palmitic acid metabolism promotes the formation of renal calcium-oxalate stones through ferroptosis induced by polyunsaturated fatty acids/phosphatidic acid

The pathogenesis of renal calcium-oxalate (CaOx) stones is complex and influenced by various metabolic factors. In parallel, palmitic acid (PA) has been identified as an upregulated lipid metabolite in the uri...

Rui Wang, **gdong Zhang, Haotian Ren, Shiyong Qi… in Cellular and Molecular Life Sciences (2024)

Article

Increased thrombospondin-1 levels contribute to epileptic susceptibility in neonatal hyperthermia without seizures via altered synaptogenesis

Childhood febrile seizures (FS) represent one of the most common types of seizures and may lead to severe neurological damage and an increased risk of epilepsy. However, most children with fevers do not show c...

Yujie Zhai, Yao Cheng, Yi Yuan, **anfeng Meng, Yang Li, Yan Wang… in Cell Death Discovery (2024)

Article

GITRL impairs hepatocyte repopulation by liver progenitor cells to aggravate inflammation and fibrosis by GITR⁺CD8⁺ T lymphocytes in CDE Mice

As an alternative pathway for liver regeneration, liver progenitor cells and their derived ductular reaction cells increase during the progression of many chronic liver diseases. However, the mechanism underly...

Li Li, Yu He, Kai Liu, Lin Liu, Shan Shan, Helin Liu, Jiangbo Ren… in Cell Death & Disease (2024)

Article

Mechanism of miR-7 mediating TLR4/TRAF6/NF-κB inflammatory pathway in colorectal cancer

This study is aimed at investigating the roles of Toll-like receptor 4 (TLR4) and microRNA-7 (miR-7) in colorectal cancer (CRC) development and progression. We assessed TLR4 and miR-7 expression in CRC cells a...

Jianfeng Ren, Bing Han, ** Feng, Gang Shao… in Functional & Integrative Genomics (2024)

Article

Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation of melanoma by directly binding to DND1

Circular RNAs (circRNAs) have been documented to play crucial roles in the biology of various cancers. However, their investigation in melanoma is still at an early stage, particularly as a broader mechanism b...

Yang Yang, Jianrui Li, Chuanyuan Wei, Lu Wang, Zixu Gao… in Cell Biology and Toxicology (2024)

Article

Vascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia

Vascular smooth muscle cell (VSMC) proliferation is the leading cause of vascular stenosis or restenosis. Therefore, investigating the molecular mechanisms and pivotal regulators of the proliferative VSMC phen...

Chao Su, Mingxia Liu, Xuyang Yao, Wei Hao… in Cellular and Molecular Life Sciences (2024)

Article

CHEK2 knockout is a therapeutic target for TP53-mutated hepatocellular carcinoma

Currently, there is still a lack of novel and effective drug targets to improve the prognosis of hepatocellular carcinoma (HCC). Additionally, the role of CHEK2 in HCC has not been reported yet. The eQTLgen da...

Yuyan Chen, Zhengyi Zhu, **ngyu Wu, Hui Li, Wenxian Guan… in Cell Death Discovery (2024)

Article

Targeting PAK4 reverses cisplatin resistance in NSCLC by modulating ER stress

Chemoresistance poses a significant impediment to effective treatments for non-small-cell lung cancer (NSCLC). P21-activated kinase 4 (PAK4) has been implicated in NSCLC progression by invasion and migration. ...

Shixin Liu, **shan Yang, Lu Wang, **aofang Zou, Dongdong Zhang… in Cell Death Discovery (2024)