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Article
Open AccessPreliminary effectiveness of breast cancer screening among 1.22 million Chinese females and different cancer patterns between urban and rural women
To determine the preliminary effectiveness of breast cancer screening among Chinese females, 1226714 women aged 35–69 years first received clinical breast examinations. Urban women with suspected cancer receiv...
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Article
Open AccessTissue-specific Co-expression of Long Non-coding and Coding RNAs Associated with Breast Cancer
Inference of the biological roles of lncRNAs in breast cancer development remains a challenge. Here, we analyzed RNA-seq data in tumor and normal breast tissue samples from 18 breast cancer patients and 18 hea...
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Article
Open AccessGenome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma
Basal cell carcinoma (BCC) is the most common cancer worldwide with an annual incidence of 2.8 million cases in the United States alone. Previous studies have demonstrated an association between 21 distinct ge...
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Article
Open AccessGenome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma
Cutaneous squamous cell carcinoma represents the second most common cutaneous malignancy, affecting 7–11% of Caucasians in the United States. The genetic determinants of susceptibility to cutaneous squamous ce...
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Article
Open AccessNew loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716...
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Article
Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
Matthew Law, Mark Iles and colleagues report the results of a large-scale genome-wide meta-analysis of cutaneous malignant melanoma. They confirm previously reported association signals and identify five new s...
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Article
Open AccessGenome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility
Psoriasis is a common inflammatory skin disease with complex genetics and different degrees of prevalence across ethnic populations. Here we present the largest trans-ethnic genome-wide meta-analysis (GWMA) of...
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Article
Association between BRAF V600E and NRAS Q61R mutations and clinicopathologic characteristics, risk factors and clinical outcome of primary invasive cutaneous melanoma
Previous studies suggest that solar UV exposure in early life is predictive of cutaneous melanoma risk in adulthood, whereas the relation of BRAF mutation with sun exposure and disease prognosis has been less ...
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Article
Invasive cutaneous squamous cell carcinoma incidence in US health care workers
Little data on cutaneous squamous cell carcinoma (SCC) epidemiology within the United States are currently available. Prior studies have focused on populations outside of the United States or been limited to r...
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Article
No association between vitamin D intake and incident psoriasis among US women
We investigated the association between dietary, supplementary and total vitamin D intake and incident psoriasis in women. A prospective study was performed of 70,437 US female nurses aged 47–74 enrolled in th...
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Article
A genome-wide association study of severe teenage acne in European Americans
Despite the family aggregation of severe teenage acne, the genetic basis of this common skin condition remains unclear. We conducted a genome-wide association study (GWAS) on severe teenage acne in 928 Europea...
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Article
CXCR4 pathway associated with family history of melanoma
Genetic predisposition plays a major role in the etiology of melanoma, but known genetic markers only account for a limited fraction of family-history-associated melanoma cases. Expression microarrays have of...
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Article
Obesity-related genetic variants, human pigmentation, and risk of melanoma
Previous biological studies showed evidence of a genetic link between obesity and pigmentation in both animal models and humans. Our study investigated the individual and joint associations between obesity-rel...
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Article
In Utero and Lactational Lanthanum Exposure Induces Olfactory Dysfunction Associated with Downregulation of βIII-tubulin and Olfactory Marker Protein in Young Rats
We evaluated the role of βIII-tubulin in the morphology of olfactory receptor neuron (ORN) and olfactory dysfunction in offspring caused by prenatal and postnatal lanthanum exposure. Pregnant rats were exposed...
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Article
Open AccessMelanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: study design and methods for pooling results of genetic epidemiological studies
For complex diseases like cancer, pooled-analysis of individual data represents a powerful tool to investigate the joint contribution of genetic, phenotypic and environmental factors to the development of a di...
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Article
Obesity and the incidence of skin cancer in US Caucasians
Limited information is available on the potential link between obesity and either melanoma or non-melanoma skin cancers.
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Article
Integrating pathway analysis and genetics of gene expression for genome-wide association study of basal cell carcinoma
Genome-wide association studies (GWASs) have primarily focused on marginal effects for individual markers and have incorporated external functional information only after identifying robust statistical associa...
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Article
Sphingosine-1-Phosphate Attenuates Lung Injury Induced by Intestinal Ischemia/Reperfusion in Mice: Role of Inducible Nitric-Oxide Synthase
Multiple organ failure, including acute lung injury (ALI), is a common complication of intestinal ischemia/reperfusion (I/R) injuries and contributes to its high mortality rate. Sphingosine-1-phosphate (S1P) i...
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Article
Genome-wide association study identifies three new melanoma susceptibility loci
Timothy Bishop and colleagues of the GenoMEL Consortium report a genome-wide association study for melanoma, identifying three new susceptibility loci.
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Article
Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3
Stuart MacGregor and colleagues report the results of a genome-wide association study for melanoma susceptibility in an Australian population. They identify a new melanoma susceptibility locus on chromosome 1.
