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Open AccessNeutralizing antibodies against SARS-CoV-2 virus after vaccination in patients with neurofibromatosis type 1
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Open AccessImmunosenescence: molecular mechanisms and diseases
Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms are linked to innate and adaptive immune dysfunction that accompanies aging (known as immunosenescence). During agi...
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Article
Open AccessSARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication
Viral infection in respiratory tract usually leads to cell death, impairing respiratory function to cause severe disease. However, the diversity of clinical manifestations of SARS-CoV-2 infection increases the...
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Open AccessVenetoclax and Azacitidine in Chinese patients with untreated acute myeloid leukemia ineligible for intensive chemotherapy
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Open AccessPreventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2
Effective drugs with broad spectrum safety profile to all people are highly expected to combat COVID-19 caused by SARS-CoV-2. Here we report that nelfinavir, an FDA approved drug for the treatment of HIV infec...
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Open AccessIntact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors
Phosphatidylinositol 3-kinase alpha (PI3Kα) inhibitors are currently evaluated for the therapy of esophageal squamous cell carcinoma (ESCC). It is of great importance to identify potential biomarkers to predic...
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Open AccessToripalimab combined with lenvatinib and GEMOX is a promising regimen as first-line treatment for advanced intrahepatic cholangiocarcinoma: a single-center, single-arm, phase 2 study
Advanced intrahepatic cholangiocarcinoma (ICC) has a dismal prognosis. Here, we report the efficacy and safety of combining toripalimab, lenvatinib, and gemcitabine plus oxaliplatin (GEMOX) as first-line thera...
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Open AccessLymphocyte integrins mediate entry and dysregulation of T cells by SARS-CoV-2
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Open AccessTransarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)
There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC...
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Article
Open AccessDRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice
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Open AccessA PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis
Pleural and peritoneal metastasis accompanied by malignant pleural effusion (MPE) or malignant ascites (MA) is frequent in patients with advanced solid tumors that originate from the lung, breast, gastrointest...
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Article
Open AccessExtrachromosomal circular DNA: biogenesis, structure, functions and diseases
Extrachromosomal circular DNA (eccDNA), ranging in size from tens to millions of base pairs, is independent of conventional chromosomes. Recently, eccDNAs have been considered an unanticipated major source of ...
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Article
Open AccessHuman umbilical cord mesenchymal stem cells for psoriasis: a phase 1/2a, single-arm study
Psoriasis is a common, chronic immune-mediated systemic disease that had no effective and durable treatment. Mesenchymal stem cells (MSCs) have immunomodulatory properties. Therefore, we performed a phase 1/2a...
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Open AccessTargeting HECTD3-IKKα axis inhibits inflammation-related metastasis
Metastasis is the leading cause of cancer-related death. The interactions between circulating tumor cells and endothelial adhesion molecules in distant organs is a key step during extravasation in hematogenous...
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Article
Open AccessHypoxia signaling in human health and diseases: implications and prospects for therapeutics
Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is linked to several biological p...
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Article
Open AccessANKFN1 plays both protumorigenic and metastatic roles in hepatocellular carcinoma
Ankyrin repeat and fibronectin type III domain containing 1 (ANKFN1) is reported to be involved in human height and developmental abnormalities, but the expression profile and molecular function of ANKFN1 in h...
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Open AccessCorrection to: Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury
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Open AccessRecombinant human erythropoietin ameliorates cognitive dysfunction of APP/PS1 mice by attenuating neuron apoptosis via HSP90β
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Open AccessTemporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury
Spinal cord injury (SCI) involves diverse injury responses in different cell types in a temporally and spatially specific manner. Here, using single-cell transcriptomic analyses combined with classic anatomica...
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Open AccessSafety and activity of WX-0593 (Iruplinalkib) in patients with ALK- or ROS1-rearranged advanced non-small cell lung cancer: a phase 1 dose-escalation and dose-expansion trial
WX-0593 (Iruplinalkib) is a novel, highly selective oral ALK and ROS1 tyrosine kinase inhibitor (TKI). In this study, the safety, antitumor activity, and pharmacokinetics of WX-0593 were evaluated in advanced ...