54 Result(s)

Article

Correction to: Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury

Chen Li, Zhourui Wu, Liqiang Zhou… in Signal Transduction and Targeted Therapy (2022)

Article

Hypoxia signaling in human health and diseases: implications and prospects for therapeutics

Molecular oxygen (O₂) is essential for most biological reactions in mammalian cells. When the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is linked to several biological p...

Zhen Luo, Mingfu Tian, Ge Yang, Qiaoru Tan… in Signal Transduction and Targeted Therapy (2022)

Article

Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis

Metastasis is the leading cause of cancer-related death. The interactions between circulating tumor cells and endothelial adhesion molecules in distant organs is a key step during extravasation in hematogenous...

Fubing Li, Huichun Liang, Hua You, Ji **ao… in Signal Transduction and Targeted Therapy (2022)

Article

Human umbilical cord mesenchymal stem cells for psoriasis: a phase 1/2a, single-arm study

Psoriasis is a common, chronic immune-mediated systemic disease that had no effective and durable treatment. Mesenchymal stem cells (MSCs) have immunomodulatory properties. Therefore, we performed a phase 1/2a...

Lamei Cheng, Siqi Wang, Cong Peng, **ao Zou… in Signal Transduction and Targeted Therapy (2022)

Article

Extrachromosomal circular DNA: biogenesis, structure, functions and diseases

Extrachromosomal circular DNA (eccDNA), ranging in size from tens to millions of base pairs, is independent of conventional chromosomes. Recently, eccDNAs have been considered an unanticipated major source of ...

Ludi Yang, Ruobing Jia, Tongxin Ge… in Signal Transduction and Targeted Therapy (2022)

Article

A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis

Pleural and peritoneal metastasis accompanied by malignant pleural effusion (MPE) or malignant ascites (MA) is frequent in patients with advanced solid tumors that originate from the lung, breast, gastrointest...

Qizhi Ma, **a He, Benxia Zhang, Fuchun Guo… in Signal Transduction and Targeted Therapy (2022)

Article

DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice

Shushu Zhou, Shimin Yuan, **tao Zhang… in Signal Transduction and Targeted Therapy (2023)

Article

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC...

Hai-Dong Zhu, Hai-Liang Li, Ming-Sheng Huang… in Signal Transduction and Targeted Therapy (2023)

Article

Lymphocyte integrins mediate entry and dysregulation of T cells by SARS-CoV-2

Mengwen Huang, **ngchao Pan, **nling Wang… in Signal Transduction and Targeted Therapy (2023)

Article

Toripalimab combined with lenvatinib and GEMOX is a promising regimen as first-line treatment for advanced intrahepatic cholangiocarcinoma: a single-center, single-arm, phase 2 study

Advanced intrahepatic cholangiocarcinoma (ICC) has a dismal prognosis. Here, we report the efficacy and safety of combining toripalimab, lenvatinib, and gemcitabine plus oxaliplatin (GEMOX) as first-line thera...

Guo-Ming Shi, **ao-Yong Huang, Dong Wu… in Signal Transduction and Targeted Therapy (2023)

Article

Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors

Phosphatidylinositol 3-kinase alpha (PI3Kα) inhibitors are currently evaluated for the therapy of esophageal squamous cell carcinoma (ESCC). It is of great importance to identify potential biomarkers to predic...

Xu Zhang, Yuxiang Wang, ** Zhang, Yanyan Shen… in Signal Transduction and Targeted Therapy (2023)

Article

Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2

Effective drugs with broad spectrum safety profile to all people are highly expected to combat COVID-19 caused by SARS-CoV-2. Here we report that nelfinavir, an FDA approved drug for the treatment of HIV infec...

Zhijian Xu, Danrong Shi, Jian-Bao Han, Yun Ling… in Signal Transduction and Targeted Therapy (2023)

Article

Venetoclax and Azacitidine in Chinese patients with untreated acute myeloid leukemia ineligible for intensive chemotherapy

Leiming **a, Wanlu Tian, Yiming Zhao… in Signal Transduction and Targeted Therapy (2023)

Article

SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication

Viral infection in respiratory tract usually leads to cell death, impairing respiratory function to cause severe disease. However, the diversity of clinical manifestations of SARS-CoV-2 infection increases the...

Pan Pan, Weiwei Ge, Zhiwei Lei, Wei luo… in Signal Transduction and Targeted Therapy (2023)

Article

Immunosenescence: molecular mechanisms and diseases

Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms are linked to innate and adaptive immune dysfunction that accompanies aging (known as immunosenescence). During agi...

Zaoqu Liu, Qimeng Liang, Yuqing Ren… in Signal Transduction and Targeted Therapy (2023)

Article

Neutralizing antibodies against SARS-CoV-2 virus after vaccination in patients with neurofibromatosis type 1

Qiao-ling Ruan, Zhi-chao Wang, Cheng-jiang Wei… in Signal Transduction and Targeted Therapy (2023)

Article

Neural stem cell-derived extracellular vesicles mitigate Alzheimer’s disease-like phenotypes in a preclinical mouse model

Ge Gao, Congcong Li, Yizhao Ma, Zhan** Liang… in Signal Transduction and Targeted Therapy (2023)

Article

Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling

The extracellular matrix (ECM) serves as signals that regulate specific cell states in tumor tissues. Increasing evidence suggests that extracellular biomechanical force signals are critical in tumor progressi...

Cong Li, Shi Qiu, **aohan Liu, Fengzhu Guo… in Signal Transduction and Targeted Therapy (2023)

Article

BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis

VEGF inhibitors are one of the most successful antiangiogenic drugs in the treatment of many solid tumors. Nevertheless, pancreatic adenocarcinoma (PAAD) cells can reinstate tumor angiogenesis via activation o...

Chongbiao Huang, Hui Li, Yang Xu, Chao Xu… in Signal Transduction and Targeted Therapy (2023)

Article

Nanoparticle-based multivalent human antibodies offer potent and broad neutralization against Omicron sublineages

Yizhen Wang, Feibo Song, Siling Wang… in Signal Transduction and Targeted Therapy (2023)