123 Result(s)
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Open AccessMutational analysis of epidermolysis bullosa in Taiwan by whole-exome sequencing complemented by RNA sequencing: a series of 77 patients
Epidermolysis bullosa (EB) is a heterogeneous group of hereditary skin diseases characterized by skin fragility. Primary data on Taiwanese population remain scarce.
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Open AccessMass testing and characterization of 20-inch PMTs for JUNO
Main goal of the JUNO experiment is to determine the neutrino mass ordering using a 20 kt liquid-scintillator detector. Its key feature is an excellent energy resolution of at least 3% at 1 MeV, for which its ...
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Article
Open AccessHK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma
Extracellular vesicles play crucial roles in intercellular communication in the tumor microenvironment. Here we demonstrate that in hepatic fibrosis, TGF-β stimulates the palmitoylation of hexokinase 1 (HK1) i...
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Open AccessSARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl− accumulation in respiratory epithelium
SARS-CoV-2, the culprit pathogen of COVID-19, elicits prominent immune responses and cytokine storms. Intracellular Cl− is a crucial regulator of host defense, whereas the role of Cl− signaling pathway in modulat...
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Prototype of the readout electronics for the RICH PID detector in the STCF
The ring imaging Cherenkov (RICH) detector for particle identification (PID) is being evaluated for the future super tau-charm facility (STCF) complex. In this work, the prototype readout electronics for the R...
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Open AccessDam** signatures at JUNO, a medium-baseline reactor neutrino oscillation experiment
We study dam** signatures at the Jiangmen Underground Neutrino Observatory (JUNO), a medium-baseline reactor neutrino oscillation experiment. These dam** signatures are motivated by various new physics mod...
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Open AccessLong-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson’s disease mouse model
Growing evidence suggests an association between Parkinson’s disease (PD) and diabetes mellitus (DM). At the cellular level, long-term elevated levels of glucose have been shown to lead to nigrostriatal degene...
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Mechanism of corrosion fatigue fracture of friction stir welding joints of 7075 aluminium alloy in 3.5% NaCl solution
The corrosion fatigue fracture mechanism of friction stir welding (FSW) joints of 7075 aluminium alloy in 3.5% NaCl solution is investigated. The corrosion fatigue crack source originates from the junction of ...
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Article
V2CTx MXene and its derivatives: synthesis and recent progress in electrochemical energy storage applications
With the continuous development of two-dimensional (2D) transition metal carbides and nitrides (collectively referred to as MXene). Nowadays, more than 70 MXene materials have been discovered, and the number i...
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Open AccessLong-term outcomes of transanal endoscopic microsurgery for the treatment of rectal neuroendocrine tumors
Transanal endoscopic microsurgery (TEM) has been accepted worldwide for the treatment of local rectal lesions. We aimed to assess the efficacy and safety of TEM in the treatment of rectal neuroendocrine tumors...
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The responses of detoxification enzyme and gene expression in western flower thrips, Frankliniella occidentalis, to new challenging hosts
The western flower thrips, Frankliniella occidentalis (Pergande) is an economically important invasive pest. It shows different preferences for various vegetables. This study investigated the responses of detoxif...
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Open AccessSix-month follow-up of functional status in discharged patients with coronavirus disease 2019
The long-term functional outcome of discharged patients with coronavirus disease 2019 (COVID-19) remains unresolved. We aimed to describe a 6-month follow-up of functional status of COVID-19 survivors.
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Open AccesscircCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis
Circular RNAs (circRNAs) have been indicated as potentially critical mediators in various types of tumor progression, generally acting as microRNA (miRNA) sponges to regulate downstream gene expression. Howeve...
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Open AccessRadioactivity control strategy for the JUNO detector
JUNO is a massive liquid scintillator detector with a primary scientific goal of determining the neutrino mass ordering by studying the oscillated anti-neutrino flux coming from two nuclear power plants at 53 ...
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Open AccessThe design and sensitivity of JUNO’s scintillator radiopurity pre-detector OSIRIS
The OSIRIS detector is a subsystem of the liquid scintillator filling chain of the JUNO reactor neutrino experiment. Its purpose is to validate the radiopurity of the scintillator to assure that all components...
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Open AccessA de novo variant of POLR3B causes demyelinating Charcot-Marie-Tooth disease in a Chinese patient: a case report
Charcot-Marie-Tooth (CMT) disease is a group of inherited peripheral neuropathies, which are subdivided into demyelinating and axonal forms. Biallelic mutations in POLR3B are the well-established cause of hypomye...
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Open AccessJUNO sensitivity to low energy atmospheric neutrino spectra
Atmospheric neutrinos are one of the most relevant natural neutrino sources that can be exploited to infer properties about cosmic rays and neutrino oscillations. The Jiangmen Underground Neutrino Observatory ...
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Correction to: Progression-free survival at 24 months and subsequent survival of patients with extranodal NK/T-cell lymphoma: a China Lymphoma Collaborative Group (CLCG) study
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Open AccessRutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer’s disease
Tau pathology is a hallmark of Alzheimer’s disease (AD) and other tauopathies. During disease progression, abnormally phosphorylated forms of tau aggregate and accumulate into neurofibrillary tangles, leading ...
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A Survey of Text Summarization Approaches Based on Deep Learning
Automatic text summarization (ATS) has achieved impressive performance thanks to recent advances in deep learning (DL) and the availability of large-scale corpora. The key points in ATS are to estimate the sal...