306 Result(s)

Article

USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1

Ubiquitin-specific protease 4 (USP4) represents a potential oncogene involved in various human cancers. Nevertheless, the biological roles and precise mechanism of USP4 in esophageal squamous cell carcinoma (E...

Hongdian Zhang, Youming Han, Wanyi **ao, Yongyin Gao, Zhilin Sui… in Cell Death & Disease (2023)

Article

A novel c-Met/TRK inhibitor 1D228 efficiently inhibits tumor growth by targeting angiogenesis and tumor cell proliferation

Multiple tumors are synergistically promoted by c-Met and TRK, and blocking their cross-signalling pathway may give better effects. In this study, we developed a tyrosine kinase inhibitor 1D228, which exhibite...

Baijiao An, Wenyan Nie, **hui Hu, Yangyang Fan, Haoran Nie… in Cell Death & Disease (2023)

Article

Inhibition of LSD1 induces ferroptosis through the ATF4-xCT pathway and shows enhanced anti-tumor effects with ferroptosis inducers in NSCLC

Lysine-specific demethylase 1 (LSD1) has been identified as an important epigenetic target, and recent advances in lung cancer therapy have highlighted the importance of targeting ferroptosis. However, the pre...

Linna Du, Han Yang, Yufei Ren, Yanli Ding, Yichao Xu, **aolin Zi… in Cell Death & Disease (2023)

Article

Cryo-EM structures of SARS-CoV-2 BA.2-derived subvariants spike in complex with ACE2 receptor

Yaning Li, Chang Ren, Ya** Shen, Yuanyuan Zhang, ** Chen… in Cell Discovery (2023)

Article

RACK1 facilitates breast cancer progression by competitively inhibiting the binding of β-catenin to PSMD2 and enhancing the stability of β-catenin

The receptor for activated C kinase 1 (RACK1) is a key scaffolding protein with multifunctional and multifaceted properties. By mediating protein-protein interactions, RACK1 integrates multiple intracellular s...

Ruinan Tian, Jianfei Tian, **aoyan Zuo, Sixin Ren, He Zhang… in Cell Death & Disease (2023)

Article

Kidney tubular epithelial cells control interstitial fibroblast fate by releasing TNFAIP8-encapsulated exosomes

Kidney fibrosis, characterized by the activation and expansion of the matrix-producing fibroblasts, is the common outcome of chronic kidney disease (CKD). While fibroblast proliferation is well studied in CKD,...

** Liu, Zhao Liu, Cong Wang, **hua Miao, Shan Zhou, Qian Ren… in Cell Death & Disease (2023)

Article

USP39 promotes hepatocellular carcinogenesis through regulating alternative splicing in cooperation with SRSF6/HNRNPC

Abnormal alternative splicing (AS) caused by alterations in spliceosomal factors is implicated in cancers. Standard models posit that splice site selection is mainly determined by early spliceosomal U1 and U2 ...

**gyi Zheng, Shasha Wu, Mao Tang, Shaoyan **, Yanchen Wang… in Cell Death & Disease (2023)

Article

SYVN1-mediated ubiquitylation directs localization of MCT4 in the plasma membrane to promote the progression of lung adenocarcinoma

Tumour cells mainly generate energy from glycolysis, which is commonly coupled with lactate production even under normoxic conditions. As a critical lactate transporter, monocarboxylate transporter 4 (MCT4) is...

Meng Zhao, Chen Huang, Lexin Yang, Boyu Pan, Shuting Yang… in Cell Death & Disease (2023)

Article

The DDUP protein encoded by the DNA damage-induced CTBP1-DT lncRNA confers cisplatin resistance in ovarian cancer

Sustained activation of DNA damage response (DDR) signaling has been demonstrated to play vital role in chemotherapy failure in cancer. However, the mechanism underlying DDR sustaining in cancer cells remains ...

Liangliang Ren, **ngrong Qing, Jihong Wei, Haixin Mo, Yuanji Liu… in Cell Death & Disease (2023)

Article

HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation

Lysine succinylation is one of the major post-translational modifications occurring on histones and is believed to have significant roles in regulating chromatin structure and function. Currently, histone desu...

Jialun Li, Lu Lu, Lingling Liu, Xuelian Ren, Jiwei Chen, **ngzhi Yin… in Cell Discovery (2023)

Article

Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1

Tumor-derived exosomes and their contents promote cancer metastasis. Phosphoglycerate mutase 1 (PGAM1) is involved in various cancer-related processes. Nevertheless, the underlying mechanism of exosomal PGAM1 ...

Jun-qi Luo, Tao-wei Yang, Jun Wu, Hou-hua Lai, Li-bin Zou… in Cell Death & Disease (2023)

Article

The Fe–S cluster assembly protein IscU2 increases α-ketoglutarate catabolism and DNA 5mC to promote tumor growth

IscU2 is a scaffold protein that is critical for the assembly of iron–sulfur (Fe–S) clusters and the functions of Fe–S-containing mitochondrial proteins. However, the role of IscU2 in tumor development remains...

**aojun Ren, Jimei Yan, Qiongya Zhao, **nzhu Bao, **nyu Han, Chen Zheng… in Cell Discovery (2023)

Article

FOXO1 regulates Th17 cell-mediated hepatocellular carcinoma recurrence after hepatic ischemia-reperfusion injury

Hepatic ischemia-reperfusion injury (IRI) is considered as an effecting factor for hepatocellular carcinoma (HCC) recurrence. Th17/Treg cells are a pair of essential components in adaptive immune response in l...

Haozhen Ren, Yuyan Chen, Zhengyi Zhu, **kun **a, Shujun Liu… in Cell Death & Disease (2023)

Article

KLF12 promotes the proliferation of breast cancer cells by reducing the transcription of p21 in a p53-dependent and p53-independent manner

Breast cancer is the most common cancer affecting women worldwide. Many genes are involved in the development of breast cancer, including the Kruppel Like Factor 12 (KLF12) gene, which has been implicated in the ...

Yanan Li, Shu**g Li, **aoxia Shi, Zhiqiang **n, Yuxi Yang… in Cell Death & Disease (2023)

Article

Sox13 and M2-like leukemia-associated macrophages contribute to endogenous IL-34 caused accelerated progression of acute myeloid leukemia

Interleukin 34 (IL-34) mainly plays physiologic and pathologic roles through the sophisticated multi-ligand signaling system, macrophage colony-stimulating factor (M-CSF, CSF-1)/IL-34-CSF-1R axis, which exhibi...

Dongyue Zhang, **aoxi Cui, Yifei Li, Rong Wang, Hao Wang, Yibo Dai… in Cell Death & Disease (2023)

Article

A novel microRNA-182/Interleukin-8 regulatory axis controls osteolytic bone metastasis of lung cancer

Bone metastasis is one of the main complications of lung cancer and most important factors that lead to poor life quality and low survival rate in lung cancer patients. However, the regulatory mechanisms under...

Ming-Na Zhao, Ling-Fei Zhang, Zhen Sun, Li-Hua Qiao, Tao Yang… in Cell Death & Disease (2023)

Article

Cryptochrome 2 acetylation attenuates its antiproliferative effect in breast cancer

Breast cancer is the most commonly diagnosed cancer, and its global impact is increasing. Its onset and progression are influenced by multiple cues, one of which is the disruption of the internal circadian clo...

Kangkai **a, Shu**g Li, Yuxi Yang, **aoxia Shi, Binggong Zhao… in Cell Death & Disease (2023)

Article

TIPE3 represses head and neck squamous cell carcinoma progression via triggering PGAM5 mediated mitochondria dysfunction

Mitochondria are essential organelles in balancing oxidative stress and cell death during cancer cell proliferation. Rapid tumor growth induces tremendous stress on mitochondria. The mammalian tumor necrosis f...

Wei Chen, **juan Chen, Lixuan Wang, Rongchun Yang, Weilin Zhang… in Cell Death & Disease (2023)

Article

CD36⁺ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor

Hepatocellular carcinoma (HCC) is an immunotherapy-resistant malignancy characterized by high cellular heterogeneity. The diversity of cell types and the interplay between tumor and non-tumor cells remain to b...

Gui-Qi Zhu, Zheng Tang, Run Huang, Wei-Feng Qu, Yuan Fang, Rui Yang… in Cell Discovery (2023)

Article

Identification of matrix-remodeling associated 5 as a possible molecular oncotarget of pancreatic cancer

Pancreatic cancer has an extremely poor prognosis. Here we examined expression, potential functions and underlying mechanisms of MXRA5 (matrix remodeling associated 5) in pancreatic cancer. Bioinformatics stud...

Shi-qing Peng, **ao-ren Zhu, Ming-zhi Zhao, Yi-fan Zhang… in Cell Death & Disease (2023)