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Effects of supernatants of polymorphonuclear neutrophils recruited by different inflammatory substances on mitogen responses of lymphocytes
Two different substances, glycogen and thioglycollate, were used to recruit early peritoneal exudate cells (4 h). In the acute phase of the inflammatory response the cellular infiltrate is large, and the predo...
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Interaction of Ia antigen-bearing polymorphonuclear leukocytes and murine splenocytes
Polymorphonuclear leukocytes (PMN) were induced in the peritoneum of a Balb/c mouse by ip injection ofFusobacterium nucleatum (FN) (>95% PMN). A subpopulation of PMN harvested bore Ia surface antigens and stimula...
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Cancer, its Complications, and the Head and Neck
Few diseases are as complex in their biology, physiology, pathology, or management as cancer [1, 2]. In addition, the disease concurrently has extensive psychological impact on patients. Consequently, the diag...
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Nanoparticulate Hydroxyapatite Enhances the Bioactivity of a Resorbable Bone Graft
A nanoparticulate-hydroxyapatite filler augmented osteointegration within a resorbable polymer based bone graft substitute designed for orthopaedic and periodontal applications. The unsaturated polyester poly(...
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The pathobiology of mucositis
Mucositis is a common toxicity of antineoplastic radiation and drug therapies, and is associated with several adverse symptomatic, health and economic outcomes...
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Is oral mucositis an inevitable consequence of intensive therapy for hematologic cancers?
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Palifermin in Myelotoxic Therapy-Induced Oral Mucositis
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Can oral glutamine prevent mucositis in children undergoing hematopoietic stem-cell transplantation?
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Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis
The pathobiology of alimentary tract (AT) mucositis is complex and there is limited information about the events which lead to the mucosal damage that occurs during cancer treatment. Various transcription fact...
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Is the pathobiology of chemotherapy-induced alimentary tract mucositis influenced by the type of mucotoxic drug administered?
Alimentary tract (AT) mucositis is a serious problem complicating cancer treatment, however, its pathobiology remains incompletely understood. Nuclear factor-κB (NF-κB) and pro-inflammatory cytokines are consi...
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Role of the cyclooxygenase pathway in chemotherapy-induced oral mucositis: a pilot study
Oral mucositis can be a significant and dose-limiting complication of high-dose cancer therapy. Mucositis is a particularly severe problem in patients receiving myeloablative chemotherapy prior to bone marrow ...
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Open AccessSerum amyloid P ameliorates radiation-induced oral mucositis and fibrosis
To evaluate the effect of the anti-fibrotic protein serum amyloid P (SAP) on radiation-induced oral mucositis (OM) and fibrosis in a hamster cheek-pouch model.
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Animal Models of Toxicities Caused by Anti-Neoplastic Therapy
Radiation and chemotherapy induce a wide range of acute and chronic toxicities. Not only are these associated with poor health outcomes but they also limit patients’ ability to tolerate treatment and incur sig...
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Introduction
Since Madame Curie discovered radium in 1897 and the application of radiation to treat of cancers in the days before World War I, injury to the mucosal surfaces of the mouth (oral mucositis or OM) has been a p...
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The Epidemiology and Risk Assessment of Mucositis
OM is among the most common and dreaded toxicities of cancer therapy [1]. It occurs in almost all patients who receive radiation therapy in which areas of the oral or oropharyngeal mucosa are included in the t...
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The Elements of Examination of the Oral Cavity
The clinical examination of the oral cavity is straightforward and easily accomplished with minimum tissue manipulation or discomfort to patients. As with any physical examination, a standardized sequence and ...
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Patient-Reported Outcomes
While we rely heavily on clinician evaluation of the mouth to define the course of mucositis, patient-reported outcomes (PROs) provide an important component to the overall assessment of the condition. PROs ar...
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Current Approaches to the Management of Oral Mucositis
Despite its frequency, impact on patients and health and economic costs, there are currently limited evidence-based options for the prevention or treatment of OM. A number of guidelines for the management of O...
