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Article
Erratum: Outcome of relapsed infant acute lymphoblastic leukemia treated on the interfant-99 protocol
Correction to: Leukemia (2016); 30(5), 1184–1187; doi:10.1038/leu.2015.246 Following the publication of this article the authors noted that the labels in Figures 1b and d have been switched. The correct labels...
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Article
Next-generation sequencing indicates false-positive MRD results and better predicts prognosis after SCT in patients with childhood ALL
Minimal residual disease (MRD) monitoring via quantitative PCR (qPCR) detection of Ag receptor gene rearrangements has been the most sensitive method for predicting prognosis and making post-transplant treatme...
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Article
Outcome of relapsed infant acute lymphoblastic leukemia treated on the interfant-99 protocol
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Article
miR-139-5p controls translation in myeloid leukemia through EIF4G2
MicroRNAs (miRNAs) are crucial components of homeostatic and developmental gene regulation. In turn, dysregulation of miRNA expression is a common feature of different types of cancer, which can be harnessed t...
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Article
Additional treatment with 2-Chloro-2-Deoxyadenosine during consolidation in children with high-risk acute myeloid leukemia does not improve survival
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Article
Unique BHLHB3 overexpression in pediatric acute myeloid leukemia with t(6;11)(q27;q23)
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Article
Open AccessT-cell receptor Vβ skewing frequently occurs in refractory cytopenia of childhood and is associated with an expansion of effector cytotoxic T cells: a prospective study by EWOG-MDS
Immunosuppressive therapy (IST), consisting of antithymocyte globulin and cyclosporine A, is effective in refractory cytopenia of childhood (RCC), suggesting that, similar to low-grade myelodysplastic syndrome...
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Article
miR-9 is a tumor suppressor in pediatric AML with t(8;21)
MicroRNAs (miRNAs) play a pivotal role in the regulation of hematopoiesis and development of leukemia. Great interest emerged in modulating miRNA expression for therapeutic purposes. In order to identify miRNA...
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Article
CD2-positive B-cell precursor acute lymphoblastic leukemia with an early switch to the monocytic lineage
Switches from the lymphoid to myeloid lineage during B-cell precursor acute lymphoblastic leukemia (BCP-ALL) treatment are considered rare and thus far have been detected in MLL-rearranged leukemia. Here, we d...
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Article
The clinical relevance of minor paroxysmal nocturnal hemoglobinuria clones in refractory cytopenia of childhood: a prospective study by EWOG-MDS
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Article
Applicability of a reproducible flow cytometry scoring system in the diagnosis of refractory cytopenia of childhood
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Article
Evaluation of WT1 expression in bone marrow vs peripheral blood samples of children with acute myeloid leukemia—impact on minimal residual disease detection
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Article
The clinical relevance of BAALC and ERG expression levels in pediatric AML
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Chapter and Conference Paper
Parallel Solvers for Numerical Upscaling
This contribution deals with numerical upscaling of the elastic material behaviour, namely of geocomposites, from microscale to macroscale through finite element analysis. This computationally demanding task r...
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Article
Real-time PCR quantification of major Wilms’ tumor gene 1 (WT1) isoforms in acute myeloid leukemia, their characteristic expression patterns and possible functional consequences
Wilms’ tumor gene 1 (WT1) functions including some contradictory effects may be explained by the presence and interactions of its isoforms, however, their evaluation has been so far complicated by several technic...
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Article
Favorable outcome in infants with AML after intensive first- and second-line treatment: an AML-BFM study group report
Infants <1 year of age have a high prevalence of prognostically unfavorable leukemias and a presumed susceptibility to treatment-related toxicities. A total of 125 infants with acute myeloid leukemia (AML) wer...
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Article
Long-term results of national treatment trials in childhood acute lymphoblastic leukaemia in several Middle/East European countries
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Article
History of treatment and long-term outcome in children with acute lymphoblastic leukemia in the Czech Republic
PURPOSE: Treatment of childhood acute lymphoblastic leukemia (ALL) was unified in the year 1986 in the Czech Republic using BFM protocols. PATIENTS AND METHODS: Children were treated in 10 and later on in 8 ce...
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Article
Signature profiles of CMV-specific T-cells in patients with CMV reactivation after hematopoietic SCT
Depletion of cellular immunity as a consequence of conditioning before allogeneic hematopoietic SCT (HSCT) frequently results in CMV reactivation, which may in turn lead to life-threatening infections and requ...
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Article
Hematopoietic stem cell transplantation for advanced myelodysplastic syndrome in children: results of the EWOG-MDS 98 study
We report on the outcome of children with advanced primary myelodysplastic syndrome (MDS) transplanted from an HLA-matched sibling (MSD) or an unrelated donor (UD) following a preparative regimen with busulfan...