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Article
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Recently, common variants on human chromosome 8q24 were found to be associated with prostate cancer risk. While conducting a genome-wide association study in the Cancer Genetic Markers of Susceptibility projec...
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Article
Multiple loci identified in a genome-wide association study of prostate cancer
We followed our initial genome-wide association study (GWAS) of 527,869 SNPs on 1,172 individuals with prostate cancer and 1,157 controls of European origin—nested in the Prostate, Lung, Colorectal, and Ovaria...
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Article
Variation in KLK genes, prostate-specific antigen and risk of prostate cancer
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Article
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer
Stephen Chanock and colleagues report a genome-wide association study of pancreatic cancer. They identify common variants at the ABO blood group locus associated with susceptibility to pancreatic cancer, consi...
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Article
Identification of a new prostate cancer susceptibility locus on chromosome 8q24
Meredith Yeager and colleagues with the Cancer Genetics Markers of Susceptibility (CGEMS) initiative report a new association to prostate cancer at chromosome 8q24. This defines a new locus, region 4, which sh...
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Article
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33
Stephen Chanock and colleagues identify three new susceptibility loci for pancreatic cancer on chromosomes 13q22.1, 1q32.1 and 5p15.33. The association signal at 13q22.1 maps to a large nongenic region, wherea...
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Article
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
Montserrat Garcia-Closas and colleagues report a genome-wide association study for bladder cancer. They identify three new susceptibility loci on chromosomes 22q13.1, 19q12 and 2q37.1.
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Article
Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3
Paul Brennan, Stephen Chanock and colleagues performed a genome-wide association study for renal carcinoma. They identified two genetic susceptibility loci.
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Article
Lack of Association of the N-acetyltransferase NAT1*10 Allele with Prostate Cancer Incidence, Grade, or Stage Among Smokers in Finland
Genetic variations in xenobiotic metabolizing genes can influence susceptibility to many environmentally induced cancers. Inheritance of the N-acetyltransferase 1 allele (NAT1*10), linked with increased metabolic...
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Article
Open AccessFine map** the KLK3 locus on chromosome 19q13.33 associated with prostate cancer susceptibility and PSA levels
Measurements of serum prostate-specific antigen (PSA) protein levels form the basis for a widely used test to screen men for prostate cancer. Germline variants in the gene that encodes the PSA protein (KLK3) have...
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Article
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study
Rosalind Eeles and colleagues report a multistage genome-wide association study of prostate cancer, identifying seven new prostate cancer susceptibility loci.
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Article
Improved imputation of common and uncommon SNPs with a new reference set
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Article
Detectable clonal mosaicism and its relationship to aging and cancer
Luis Pérez-Jurado, Stephen Chanock and colleagues detect clonal chromosomal abnormalities in peripheral blood or buccal samples from individuals in the general population. They show that the frequency of such ...
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Article
Open AccessY chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry
Genetic variation on the Y chromosome has not been convincingly implicated in prostate cancer risk. To comprehensively analyze the role of inherited Y chromosome variation in prostate cancer risk in individual...
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Article
Genome-wide association study of glioma and meta-analysis
Gliomas account for approximately 80 % of all primary malignant brain tumors and, despite improvements in clinical care over the last 20 years, remain among the most lethal tumors, underscoring the need for ga...
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Article
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genoty** array
Rosalind Eeles and colleagues report meta-analysis of genome-wide association studies for prostate cancer and genoty** on the custom iCOGS array in 25,074 cases and 24,272 controls from 32 studies available ...
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Article
Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders
Ruth Loos and colleagues report a meta-analysis of genome-wide association studies in 181,171 individuals identifying 14 new loci associated with heart rate and test these for association with cardiac conducti...
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Article
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
Susan Slager and colleagues report a meta-analysis of genome-wide association studies for chronic lymphocytic leukemia (CLL). They identify nine loci newly associated with CLL.
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Article
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer
Richard Houlston, Maria Teresa Landi and colleagues report the identification of large-effect associations for squamous lung cancer with rare variants in BRCA2 and CHEK2.
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Article
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
Rachael Stolzenberg-Solomon, Laufey Amundadottir and colleagues report a genome-wide association study of pancreatic cancer. They identify four new susceptibility loci.