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Article
Cigarette smoking and liver cancer among US veterans
The relationship of tobacco use with risk of primary liver cancer was investigated using data from a 26-year mortality follow-up of nearly 250,000 US veterans, mostly from World War I. Significantly increased ...
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Article
Cigarette smoking and leukemia: results from the Lutheran Brotherhood Cohort Study
In a 20-year follow-up (1966–86) of 17,633 White males who described tobacco use in a mailed questionnaire sent in 1966, there were 74 deaths from leukemia (including 30 myeloid, 30 lymphatic, and 14 other and...
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Article
Oral contraceptives and primary liver cancer among young women
The association of oral contraceptive use with liver cancer was examined in a study of 76 deaths from primary liver cancer, 22 deaths from cancer of the intrahepatic bile ducts, and 629 controls among women ag...
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Article
Alcoholism and cancer risk: a population-based cohort study
The incidence of cancer was studied in a population-based cohort of 9,353 individuals (8,340 men and 1,013 women) with a discharge diagnosis of alcoholism in 1965–83, followed up for 19 years (mean 7.7). After...
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Article
Risk factors for small intestine cancer
Small intestine cancer is relatively rare. Clinical reports have suggested that several medical conditions may predispose to increased occurrence of this cancer, but otherwise its etiology is unknown. In one o...
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Article
Risk Factors for Male Breast Cancer (United States)
Objectives: The etiology of male breast cancer is obscure, although an excess risk has been associated with Klinefelter syndrome, testicular disorders, benign breast disease including gynecomastia, use of exog...
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Article
Case-control study of diet and prostate cancer in China
Introduction: A higher incidence of prostate cancer is observed in the Western world than in Asian countries. Although it is relatively rare in China, an increased incidence has been reported in recent years. ...
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Chapter
The Expanded Poly-Q Length Within AR and AR Coregulator AIB1 and Their Clinical Implications
The cloning of the androgen receptor gene in 1988 (Chang et al., 1988) and identification of androgen receptor (AR) coactivators have greatly improved our understanding of intracellular androgenic action and the ...
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Article
Diabetes mellitus and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
A history of diabetes has been fairly consistently related to a reduced prostate cancer risk, but previous investigations have not always addressed whether the relation with diabetes varies by prostate cancer ...
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Chapter
Androgen-Metabolic Genes in Prostate Cancer Predisposition and Progression
Prostate cancer is the most common nonskin cancer and the second leading cause of cancer deaths among men in most Western countries, including the US and Australia. Despite its high morbidity and mortality, th...
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Article
Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China
We examined the associations between 21 single nucleotide polymorphisms (SNPs) of eight lipid metabolism genes and lipid levels in a Chinese population. This study was conducted as part of a population-based s...
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Chapter
Androgens and Prostate Cancer
Prostate cancer is the most common nonskin cancer among American men and the third leading cause of cancer deaths. Research data over many years of study support the role of androgen in driving prostate cancer...
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Article
Intra-individual variation in serum C-reactive protein over 4 years: an implication for epidemiologic studies
Data on long-term intra-individual variability in high-sensitivity C-reactive protein (hsCRP) are needed to determine whether one measurement adequately reflects usual levels in prospective studies of on the e...
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Article
Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3
Paul Brennan, Stephen Chanock and colleagues performed a genome-wide association study for renal carcinoma. They identified two genetic susceptibility loci.
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Article
Open AccessChronic typhoid infection and the risk of biliary tract cancer and stones in Shanghai, China
Previous studies have shown a positive association between chronic typhoid carriage and biliary cancers. We compared serum Salmonella enterica serovar Typhi antibody titers between biliary tract cancer cases, bil...
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Article
Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21
Christopher Haiman and colleagues report a genome-wide association study for prostate cancer in African-American males drawn from 11 epidemiological studies of prostate cancer, with replication including indiv...
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Article
Dietary carbohydrate, glycemic index, glycemic load, and risk of prostate cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort
To evaluate the associations between dietary carbohydrate, glycemic index (GI), glycemic load (GL), and incident prostate cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) coh...
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Article
Open AccessSerum estrogen levels and prostate cancer risk in the prostate cancer prevention trial: a nested case–control study
Finasteride reduces prostate cancer risk by blocking the conversion of testosterone to dihydrotestosterone. However, whether finasteride affects estrogens levels or change in estrogens affects prostate cancer ...
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Article
Medical history and the risk of biliary tract cancers in Shanghai, China: implications for a role of inflammation
Several lines of evidence suggest that inflammation may play a role in the etiology of biliary tract cancers. To examine further the role of inflammation, we evaluated the associations between self-reported in...
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Article
Improved imputation of common and uncommon SNPs with a new reference set
