1,120 Result(s)

Article

Solubilisation of Drugs in Micellar Systems Studied by Eluent Gel Permeation Chromatography

Purpose. The purpose of the study was to investigate the potential of a chromatographic method which is based on elution gel chromatography (EGPC) in the study of solubilisation of drugs in micellar solutions.

Michael Draper, Matthew Savage, John H. Collett, David Attwood… in Pharmaceutical Research (1995)

Article

Second–generation adenovirus vectors

Qing Wang, Mitchell H. Finer in Nature Medicine (1996)

Article

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene

Acute myeloid leukaemia (AMI) is a major haematopoietic malignancy characterized by the proliferation of a malignant clone of myeloid progenitor cells1,2. A reciprocal translocation, t(8;21)(q22;q22), observed...

Donald A. Yergeau, Christopher J. Hetherington, Qing Wang, Pu Zhang… in Nature Genetics (1997)

Article

KCNE1 mutations cause Jervell and Lange-Nielsen syndrome

Eric Schulze-Bahr, Qing Wang, Horst Wedekind, Wilhelm Haverkamp… in Nature Genetics (1997)

Article

De novo mutations in the CRX homeobox gene associated with Leber congenital amaurosis

Carol L. Freund, Qing-Ling Wang, Shiming Chen, Brenda L. Muskat… in Nature Genetics (1998)

Article

A mutation in NRL is associated with autosomal dominant retinitis pigmentosa

David A.R. Bessant, Annette M. Payne, Kenneth P. Mitton, Qing-Liang Wang… in Nature Genetics (1999)

Article

Polycations and cationic lipids enhance adenovirus transduction and transgene expression in tumor cells

Replication-deficient adenovirus vectors are efficient vehicles for delivering therapeutic genes into mammalian cells. However, the high doses required to produce effective gene transfer in vivo can also cause un...

Paul R Clark, Alison T Stopeck, Jacqueline L Brailey, Qing Wang… in Cancer Gene Therapy (1999)

Article

Is Neuronal Injury Caused by Hypoglycemic Coma of the Necrotic or Apoptotic Type?

In this study, we explored if a 30 minute period of hypoglycemic coma yields damage which shows some features associated with apoptosis. To that end, we induced insulin-hypoglycemic coma of 30 min duration, an...

Yi-Bing Ouyang, Qing-** He, **-An Li, Shorena Janelidze… in Neurochemical Research (2000)

Article

Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine

The breaking of immune tolerance against autologous angiogenic endothelial cells should be a useful approach for cancer therapy. Here we show that immunotherapy of tumors using fixed xenogeneic whole endotheli...

Yu-quan Wei, Qing-ru Wang, **a Zhao, Li Yang, Ling Tian, You Lu… in Nature Medicine (2000)

Article

GSTP1 polymorphisms and gastric cancer in a high-risk Chinese population

Objectives: In a population-based case–control study in Yangzhong, China, we investigated the relationship between genetic polymorphisms of GSTP1 and susceptibility to gastric cancer and its premalignant lesion,...

Veronica Wendy Setiawan, Zuo-Feng Zhang, Guo-Pei Yu, Qing-Yi Lu… in Cancer Causes & Control (2001)

Article

Predicting hepatitis B virus–positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning

Hepatocellular carcinoma (HCC) is one of the most common and aggressive human malignancies. Its high mortality rate is mainly a result of intra-hepatic metastases. We analyzed the expression profiles of HCC sa...

Qing-Hai Ye, Lun-**u Qin, Marshonna Forgues, ** He, ** Woo Kim… in Nature Medicine (2003)

Article

Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource

Schistosoma japonicum causes schistosomiasis in humans and livestock in the Asia-Pacific region. Knowledge of the genome of this parasite should improve understanding of schistosome-host interactions, biomedical ...

Wei Hu, Qing Yan, Da-Kang Shen, Feng Liu, Zhi-Dong Zhu, Huai-Dong Song… in Nature Genetics (2003)

Article

P2X7 receptor inhibition improves recovery after spinal cord injury

Secondary injury exacerbates the extent of spinal cord insults, yet the mechanistic basis of this phenomenon has largely been unexplored. Here we report that broad regions of the peritraumatic zone are charact...

**aohai Wang, Gregory Arcuino, Takahiro Takano, Jane Lin, Wei Guo Peng… in Nature Medicine (2004)

Article

Frequent loss of membranous E-cadherin in gastric cancers: A cross-talk with Wnt in determining the fate of β-catenin

The potential correlation of E-cadherin reduction and Wnt2 up-regulation in determining the intracellular distribution of β-catenin in gastric cancers was investigated by the methods of frozen tissue array-bas...

**ao-**n Cheng, Zi-Chuang Wang, **ao-Yan Chen… in Clinical & Experimental Metastasis (2005)

Article

Purification and characterization of recombinant human liver prolidase expressed in Saccharomyces cerevisiae

The recombinant human liver prolidase (rh-prolidase, EC 3.4.13.9) from the lysate supernatant of engineering yeast Saccharomyces cerevisiae was purified in two steps employing anion-exchange gradient chromatograp...

Shu-Hao Wang, Qing-Wen Zhi, Man-Ji Sun in Archives of Toxicology (2005)

Article

Construction and identification of Fas-targeting siRNA-expressing plasmid

Objective: To study the therapeutic potential of Fas inhibition in different diseases, a Fas-targeting siRNA (small interfering)-expressing plasmid was constructed. Methods: The U6 promoter cassette and siFas ...

Liu Su-hu, Zhang Wang-gang, Zhang Mei, Zhu Qing… in Journal of Zhejiang University Science B (2005)

Article

Treatment of hepatocellular carcinoma with adenoviral vector-mediated Flt3 ligand gene therapy

Fms-like tyrosine kinase 3 ligand (Flt3L) plays an important role in development and activation of dendritic cells (DCs) and natural killer cells (NK). It has been shown that administration of either tumor cel...

Hao Wang, Jianxin Dai, Sheng Hou, Weizhu Qian, Bohua Li, **g Ma… in Cancer Gene Therapy (2005)

Article

Polymorphism of the mouse gene for the interleukin 10 receptor alpha chain (Il10ra) and its association with the autoimmune phenotype

Several studies suggest that interleukin (IL)-10 pathway is involved in murine lupus, while no linkage of IL-10 gene polymorphism to disease susceptibility has been reported in studies with lupus-prone mice. S...

Zan-Mei Qi, Jun Wang, Zheng-Rong Sun, Feng-Mao Ma, Qing-Rui Zhang… in Immunogenetics (2005)

Article

Allyl Chloride-Induced Time Dependent Changes of Lipid Peroxidation in Rat Nerve Tissue

To accurately know the time-dependent changes of the lipid peroxidation and antioxidative status for elucidating the mechanism of neuropathy induced by allyl chloride (AC), the malondialdehyde (MDA), anti-reac...

Qing-Shan Wang, Ke-Qin **e, Cui-li Zhang, Ying-Jian Zhu… in Neurochemical Research (2005)