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Preclinical Models in Colorectal Cancer Drug Discovery

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Handbook of Animal Models and its Uses in Cancer Research

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Abstract

Currently, colorectal cancer (CRC) remains one of the most common causes of cancer-related death worldwide despite advances in medical therapies of CRC. Therefore, appropriate animal models of CRC are urgently needed to help understand the pathophysiological mechanism of CRC, develop new drugs, and evaluate the efficacy of new drugs at the preclinical level. At present, CRC animal models mainly include carcinogen-induced models, transplant models, and transgenic animal models. The selection of suitable modeling animals and corresponding modeling methods is the key for the success of CRC drug discovery, depending on factors such as experimental purpose, experimental cycle, and experimental technology. Here, this article reviews the pros and cons and research progress of different animal models in CRC, providing ideas and methods for further research on CRC drug discovery.

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Authors and Affiliations

  1. Colorectal Cancer Center, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China

    Ying Yang, Wen-Jian Meng & Zi-Qiang Wang

Authors
  1. Ying Yang
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  2. Wen-Jian Meng
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  3. Zi-Qiang Wang
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Editor information

Editors and Affiliations

  1. Allied Health Sciences, CARE, Chennai, Tamil Nadu, India

    Surajit Pathak

  2. Fac of Allied Health Sciences, CHRI, Chettinad Acad of Res & Education, Kelambakkam, Chennai, Tamil Nadu, India

    Antara Banerjee

  3. AGENTEM, Cukurova University, Adana, Turkey

    Atil Bisgin

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Yang, Y., Meng, WJ., Wang, ZQ. (2022). Preclinical Models in Colorectal Cancer Drug Discovery. In: Pathak, S., Banerjee, A., Bisgin, A. (eds) Handbook of Animal Models and its Uses in Cancer Research. Springer, Singapore. https://doi.org/10.1007/978-981-19-1282-5_56-1

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  • DOI: https://doi.org/10.1007/978-981-19-1282-5_56-1

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-19-1282-5

  • Online ISBN: 978-981-19-1282-5

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