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Immediate-early gene activation as a window on mechanism in the nervous system

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Immediate-Early Genes in the Central Nervous System

Abstract

Immediate early genes (IEGs) were originally described as a class of genes rapidly and transiently expressed in cells stimulated with growth factors without the requirement for de novo protein synthesis (Cochran et al. 1983). c-Fos (Curran et al. 1987), c-Jun (Angel et al. 1988; Ryseck et al. 1988; Sakai et al. 1989) and other IEGs have been shown to be transcription factors (Chiu et al. 1988; Halzonetis et al. 1988; Sassone-Corsi et al. 1988; Abate et al. 1990; Benbrook and Jones 1990; Macgregor et al. 1990) and are differentially expressed in the central nervous system following specific types of stimulation (Hunt et al. 1987; Williams et al. 1989; Wisden et al. 1990; Cole et al. 1989, Tölle et al. 1994; Morgan and Curran 1992). Indeed, evidence is accumulating to suggest that IEG changes in gene expression within the nervous system signal long term adaptation within particular neural pathways.

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Authors and Affiliations

  1. Division of Neurobiology, Laboratory of Molecular Biology, MRC Centre, Hills Road, Cambridge, CB2 2QH, UK

    S. P. Hunt, R. Jenkins & W. Wisden

  2. Laboratory of Developmental Neurobiology, National Institute of Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    L. A. McNaughton

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  1. S. P. Hunt
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  2. L. A. McNaughton
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  3. R. Jenkins
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  4. W. Wisden
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Editors and Affiliations

  1. Max-Planck-Institut für Psychiatrie Klinisches Institut, Klinische Neuropharmakologie, Kraepelinstr. 2-10, D-80804, München, Germany

    T. R. Tölle , J. Schadrack  & W. Zieglgänsberger ,  & 

Additional information

An invaluable contribution to the work presented here was made by our colleague Simon Williams who died tragically in 1992.

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© 1995 Springer-Verlag Berlin Heidelberg

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Hunt, S.P., McNaughton, L.A., Jenkins, R., Wisden, W. (1995). Immediate-early gene activation as a window on mechanism in the nervous system. In: Tölle, T.R., Schadrack, J., Zieglgänsberger, W. (eds) Immediate-Early Genes in the Central Nervous System. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79562-6_2

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  • DOI: https://doi.org/10.1007/978-3-642-79562-6_2

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