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Helicobacter pylori: Pathogenic Mechanisms

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The Stomach

Abstract

H. pylori is a bacterium which colonizes the gastric mucosa. In 1896, Salomon described spiral organisms in stomachs of man and animals [1]. It was not until 1983, when Warren and Marshall first reported the isolation of a spiral bacterium from gastric biopsies of patients with gastritis [2, 3], that the dramatic expansion of information on H. pylori (Hp) began. Its worldwide distribution and high prevalence make it one of the commonest infections in mankind [4, 5]. Hp infection is associated with chronic type B gastritis, duodenal and gastric ulcer, and gastric carcinoma [6, 7] (Tables 1 and 2).

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  1. F. A. Wyle
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  2. K. J. Chang
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  3. A. Tarnawski
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Editors and Affiliations

  1. University of Münster, Albert-Schweitzer-Str. 33, D-48149, Münster, Germany

    W. Domschke MD MD(hon) FACG (Chairman of the Department of Medicine B) (Chairman of the Department of Medicine B)

  2. University of Kraków, ul. Grzegórzecka 16, PL-31531, Kraków, Poland

    S. J. Konturek MD (Chairman of the Institute of Physiology) (Chairman of the Institute of Physiology)

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Wyle, F.A., Chang, K.J., Tarnawski, A. (1993). Helicobacter pylori: Pathogenic Mechanisms. In: Domschke, W., Konturek, S.J. (eds) The Stomach. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78176-6_14

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