Abstract
Helicobacter pylori is a Gram-negative, microaerophilic bacterium which colonises human gastric mucosa. Initially, B. Marshall and W. Warren discovered the etiological role of H. pylori in gastritis and peptic ulcers and received the Nobel Prize in Medicine in 2005. Indeed, since 1994, H. pylori has been also recognised by the WHO to be associated with gastric cancer, being the first cause of gastric adenocarcinoma based on epidemiological data and Hill’s criteria for causality. H. pylori infection is responsible for at least 90 % of non-cardia gastric cancers and is the third cause of mortality by cancer in the world with nearly one million new cases per year.
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Lehours, P., Bessède, E., Mégraud, F., Varon, C. (2015). Epidemiology of Helicobacter pylori and Mechanisms of Carcinogenesis. In: Droz, JP., Carme, B., Couppié, P., Nacher, M., Thiéblemont, C. (eds) Tropical Hemato-Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-18257-5_19
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DOI: https://doi.org/10.1007/978-3-319-18257-5_19
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