Summary
Inherited variations in alcohol and aldehyde dehydrogenases, the principal enzymes of ethanol metabolism, have been implicated in determining susceptibility to alcoholism and alcohol-related organ damage. An association between an RFLP for the alcohol dehydrogenase-2 (ADH2) gene and alcohol-induced liver damage was demonstrated in a Caucasian population. Genoty** studies revealed an increase in the ADH3 2 allele in patients with alcohol-induced cirrhosis. PCR studies of the ALDH5 gene have demonstrated diverse polymorphism within a short segment of its coding region, with marked inter-racial variation in allele frequencies. In addition, the Caucasian alcohol-induced flushing reaction has been characterised and its relationship with phenotypic polymorphism of ALDH1 examined.
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© 1994 Birkhäuser Verlag Basel/Switzerland
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Sherman, D.I.N., Ward, R.J., Yoshida, A., Peters, T.J. (1994). Alcohol and acetaldehyde dehydrogenase gene polymorphism and alcoholism. In: Jansson, B., Jörnvall, H., Rydberg, U., Terenius, L., Vallee, B.L. (eds) Toward a Molecular Basis of Alcohol Use and Abuse. Experientia, vol 71. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7330-7_29
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DOI: https://doi.org/10.1007/978-3-0348-7330-7_29
Publisher Name: Birkhäuser Basel
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