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Sarcomas

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Abstract

Soft tissue pathology encompasses a remarkably diverse assortment of more than 100 benign and malignant tumors. Two major groups of genetic events can be seen in sarcomas. The first comprises of tumors with translocations or alternatively specific activating or inactivating mutations within oncogenes or tumor suppressor genes, respectively. Often these tumors occur in a setting of simple karyotype. The second major group is associated with multiple and complex chromosomal changes. During the past 2 decades, the discovery of molecular alterations that underlie the pathogenesis of soft tissue tumors, especially in the first major group, have demonstrated their increasingly important role in mesenchymal tumor diagnostics. In this chapter we present the most updated information regarding the molecular pathogenesis of mesenchymal tumors, highlighting its importance in potential exploitation for diagnostic purposes with various ancillary techniques.

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  1. Dartmouth-Hitchcock Medical Center, Department of Pathology and Laboratory Medicine, Lebanon, NH, USA

    Konstantinos Linos

  2. Geisel School of Medicine at Dartmouth, Hanover, NH, USA

    Konstantinos Linos

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  1. Dartmouth–Hitchcock Medical Center, Lebanon, NH, USA

    Laura J. Tafe

  2. Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Maria E. Arcila

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Linos, K. (2020). Sarcomas. In: Tafe, L., Arcila, M. (eds) Genomic Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-22922-1_11

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