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Sarcomas and Related Mesenchymal Tumors

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Molecular Pathology in Clinical Practice

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Abstract

Understanding the molecular pathology of sarcomas and related mesenchymal lesions is often essential for their diagnosis. Cytogenetics and molecular cytogenetics have contributed significantly to the identification of recurrent chromosomal changes, fostering a continual refinement in the classification of these tumors. The recognition of distinctive rearrangements in tumor subsets is providing powerful tools to a field in which pathological diagnosis and clinical management are often difficult, due to both the variety of tumor phenotypes and their relative rarity. Novel technical approaches, including next-generation sequencing, are increasing the speed and throughput of molecular analysis and the application of genomic knowledge into clinical practice may radically change the management of patients with sarcomas.

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Authors and Affiliations

  1. Anatomic Pathology, Bologna University School of Medicine, Ospedale Bellaria, Via Altura 3, Bologna, 40139, Italy

    Giovanni Tallini M.D. & Dario de Biase

  2. Department of Pathology, Yale University School of Medicine, New Haven, CT, USA

    Pei Hui M.D.

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  1. Giovanni Tallini M.D.
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  2. Dario de Biase
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Correspondence to Giovanni Tallini M.D. .

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  1. Pathology and Laboratory Medicine, University of Vermont College of Medicine and University of Vermont Medical Center, Burlington, Vermont, USA

    Debra G.B. Leonard

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Tallini, G., de Biase, D., Hui, P. (2016). Sarcomas and Related Mesenchymal Tumors. In: Leonard, D. (eds) Molecular Pathology in Clinical Practice. Springer, Cham. https://doi.org/10.1007/978-3-319-19674-9_37

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  • DOI: https://doi.org/10.1007/978-3-319-19674-9_37

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