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Relationship between Metabolic Rate, Free Radicals, Differentiation and Aging: A Unified Theory

  • Chapter
Molecular Biology of Aging

Part of the book series: Basic Life Sciences ((BLSC,volume 35))

Abstract

There is presently no single, widely accepted, unifying theory of aging that is applicable to a wide spectrum of organisms. This fact has led many gerontologists to believe that mechanisms of aging may differ in various phylogenetic groups, albeit no compelling evidence or a priori reason has been forwarded to support this view. Given the basic similarity of molecular and cellular processes in living systems, it is indeed more probable that the contrary may be true, and that the underlying causal mechanisms of aging are essentially similar in all organisms. Conceptually, theories of aging can be assigned to two fundamentally different schools. One view regards aging as a continuation of the process of differentiation involving a programmed “shutdown” of genomic activity or a sequential activation of specific genes whose products have deleterious effects on cellular functions. Alternatively, aging is postulated to be a direct or indirect product of metabolic damage arising from the inadequacy of protective and reparative mechanisms.

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  1. Department of Biology, Southern Methodist University, Dallas, Texas, 75275, USA

    R. S. Sohal & R. G. Allen

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  1. R. S. Sohal
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  1. Brookhaven National Laboratory, Upton, New York, USA

    Avril D. Woodhead

  2. University of Manchester Institute of Science and Technology, Manchester, UK

    Anthony D. Blackett

  3. Council for Research Planning in Biological Sciences, Inc., Washington, DC, USA

    Alexander Hollaender

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Sohal, R.S., Allen, R.G. (1985). Relationship between Metabolic Rate, Free Radicals, Differentiation and Aging: A Unified Theory. In: Woodhead, A.D., Blackett, A.D., Hollaender, A. (eds) Molecular Biology of Aging. Basic Life Sciences, vol 35. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2218-2_4

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