Abstract
Few areas of biological research have been more frustrating than the efforts to derive a rational explanation of the mechanism of action of the thyroid hormone(s) (TH). A huge and bewildering array of observations has been published and has generated more confusion than clarification. The difficulty of successfully integrating these data has been compounded by the use of a wide range of TH dosages, from physiological (10−10 to 10−8 M) to pharmacological (up to 10−6 M) to toxic (>10−6 M); by the variation in animal condition, from completely athyroid to euthyroid to hyperthyroid; and by the use of systems varying from pure enzymes to whole animals, frequently on variable diets. The object of this chapter will be to resolve the actions of TH into two major roles and trace their development in terms of the metabolic needs and developmental requirements of all classes of vertebrates with particular emphasis on their role in amphibian metamorphosis (Shellabarger, 1964).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Ashley, H., Katti, P., and Frieden, E., 1968, Dev. Biol. 17: 293.
Cohen, P. P., Brucken, R. F., and Morris, S. M., 1978, in: Hormonal Proteins and Peptides, Volume VI (C. H. Li, ed.), pp. 273–382, Academic Press, New York.
Etkin, W., 1968, in: Metamorphosis: A Problem in Developmental Biology (W. Etkin and L. I. Gilbert, eds.), p. 313, Appleton-Century-Crofts, New York.
Evans, E. S., Rosenberg, L. L., and Simpson, M. E., 1960, Endocrinology 66: 433.
Frieden, E., and Just, J. J., 1970, in: Biochemical Actions of Hormones (G. Litwack, ed.), p. 1–52, Academic Press, New York.
Frieden, E., and Lipner, H., 1971, Biochemical Endocrinology of the Vertebrates, Prentice-Hall, Englewood Cliffs, N.J.
Frieden, E., and Yoshizato, K., 1974, Endocrinology 95: 188.
Gorbman, A., and Bern, H. A., 1962, A Textbook of Comparative Endocrinology, Wiley, New York.
Jorgensen, E. C., 1978, in: Hormonal Proteins and Peptides, Volume VI (C. H. Li, ed.), pp. 108–204, Academic Press, New York.
Jorgensen, E. C., and Andrea, T. A., 1976, Excerpta Med. Found. Int. Congr. Ser. 361: 303.
Kistler, A., Yoshizato, K., and Frieden, E., 1975, Endocrinology 97: 1025.
Mäher, M. J., and Levedahl, B., 1959, J. Exp. Zool. 140: 169.
Miyauchi, H., LaRochelle, Jr., F. T., Suzuki, M., Freeman, M., and Frieden, E., 1977, Gen. Comp. Endocrinol. 33: 254.
Mondou, P. M., and Kaltenbach, J. C., 1979, Gen. Comp. Endocrinol. 39: 343.
Oppenheimer, J. H., 1979, Science 203: 971.
Packard, G. C., 1976, Gen. Comp. Endocrinol. 28: 334.
Regard, E., Taurog, A., and Nakashima, T., 1978, Endocrinology 102: 674.
Sage, M., 1973, Am. Zool. 13: 899.
Shellabarger, C. J., 1964, in: The Thyroid Gland, Volume I (R. Pitt-Rivers and W. R. Trotter, eds.), Butterworths, London, Chap. 9, p. 187.
Spangenberg, D. B., 1974, Am. Zool. 14: 825.
Sterling, K., 1979, N. Engl. J. Med. 300: 117, 173.
Turner, C. D., and Bagnara, J. T., 1976, General Endocrinology, Saunders, Philadelphia.
Yamamoto, K., Kanski, D., and Frieden, E., 1966, Gen. Comp. Endocrinol. 6: 312.
Yoshizato, K., and Frieden, E., 1975, Nature (London) 254: 705.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Plenum Press, New York
About this chapter
Cite this chapter
Frieden, E. (1981). The Dual Role of Thyroid Hormones in Vertebrate Development and Calorigenesis. In: Gilbert, L.I., Frieden, E. (eds) Metamorphosis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3246-6_16
Download citation
DOI: https://doi.org/10.1007/978-1-4613-3246-6_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-3248-0
Online ISBN: 978-1-4613-3246-6
eBook Packages: Springer Book Archive