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Role of selenium in HIV/AIDS

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Selenium

Abstract

Selenium appears to have a multifactorial role in HIV-1 infection. Selenium status affects HIV disease progression and mortality [1] through various potential mechanisms. Selenium protects against oxidative stress through its function as a biological antioxidant required for the activity of gluthatione peroxidase. Adequate selenium status may also be essential in controlling viral emergence and evolution [2]. In addition, selenium may enhance resistance to infection through modulation of both cellular and humoral immunity. Plasma selenium levels affect interleukin production and subsequent changes in Thl/Th2 cytokine responses [3]. Interacting with selenium status, other nutritional factors are important in HIV-1 progression and mortality. The causative factors, including disease stage, nutritional status at the onset of the disease, types of treatment and compliance, and secondary infections may be acting independently or in combination. Treatment of malnutrition, and the accompanying micronutrient deficiencies, thus, requires a carefully individualized approach. This chapter will review the current research on the relationship of nutritional status to HIV-1 disease progression and mortality, as well as the factors that may affect this relationship, with emphasis on the role of selenium.

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Author information

Authors and Affiliations

  1. Division of Metabolism and Disease Prevention, Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, FL, 33136, USA

    Marianna K. Baum, Adriana Campa, Maria José Miguez-Burbano, **mena Burbano & Gail Shor-Posner

Authors
  1. Marianna K. Baum
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  2. Adriana Campa
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  3. Maria José Miguez-Burbano
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  4. **mena Burbano
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  5. Gail Shor-Posner
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Editors and Affiliations

  1. National Cancer Institute, USA

    Dolph L. Hatfield

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© 2001 Springer Science+Business Media New York

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Baum, M.K., Campa, A., Miguez-Burbano, M.J., Burbano, X., Shor-Posner, G. (2001). Role of selenium in HIV/AIDS. In: Hatfield, D.L. (eds) Selenium. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1609-5_20

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  • DOI: https://doi.org/10.1007/978-1-4615-1609-5_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5639-4

  • Online ISBN: 978-1-4615-1609-5

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