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Die Blockade der Thymidilatsynthase-Regulation über src-Kinase-Inhibition führt zur Reduktion der Chemotherapieresistenz beim 5-FU-resistenten humanen Pankreaskarzinom

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Chirurgisches Forum 2006

Part of the book series: Deutsche Gesellschaft für Chirurgie ((FORUMBAND,volume 35))

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Schlussfolgerung

Eine 5-FU-Resistenz konnte im Pankreaskarzinom erfolgreich durch Blockade der TS-Regulation über src-Kinase-Inhibition abgebaut werden. Diese Ergebnisse demonstrieren einen möglichen Mechanismus, der zur Klärung des »hemosensitizer-Effekts« der src-Kinase-Inhibition in 5-FU chemotherapie-resistenten Pankreaskarzinomen beiträgt und unterstützen damit den Einsatz von src- Kinase-Inhibitoren in Kombination mit Chemotherapie in der Therapie des Pankreaskarzinoms.

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Author information

Authors and Affiliations

  1. Chirurgische Klinik und Poliklinik-Großhadern, LMU München, München, Deutschland

    Dr. I. Ischenko, P. Camaj, E. De Toni, C. Graeb, M. Guba, K. W. Jauch & C. J. Bruns

Authors
  1. Dr. I. Ischenko
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  2. P. Camaj
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  3. E. De Toni
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  4. C. Graeb
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  5. M. Guba
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  6. K. W. Jauch
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  7. C. J. Bruns
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Corresponding author

Correspondence to I. Ischenko .

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Editors and Affiliations

  1. Klinik und Poliklinik für Viszeral-, Thorax- und Gefäßchirurgie, Universitätsklinikum Carl Gustav Carus, Fetscherstraße 74, 01307, Dresden

    H. -D. Saeger (Direktor) (Direktor)

  2. Chirurgischen Klinik und Poliklinik, Klinikum Großhadern, Marchioninistraße 15, 81366, München

    K. -W. Jauch (Direktor) (Direktor)

  3. Deutsche Gesellschaft für Chirurgie Geschäftsstelle, Luisenstraße 58/59, 10117, Berlin

    H. Bauer

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© 2006 Springer Medizin Verlag Heidelberg

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Ischenko, I. et al. (2006). Die Blockade der Thymidilatsynthase-Regulation über src-Kinase-Inhibition führt zur Reduktion der Chemotherapieresistenz beim 5-FU-resistenten humanen Pankreaskarzinom. In: Saeger, H.D., Jauch, K.W., Bauer, H. (eds) Chirurgisches Forum 2006. Deutsche Gesellschaft für Chirurgie, vol 35. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-34668-6_51

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  • DOI: https://doi.org/10.1007/3-540-34668-6_51

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-32480-5

  • Online ISBN: 978-3-540-34668-5

  • eBook Packages: Medicine (German Language)

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