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Thermally stable bioactive borosilicate glasses: Composition–structure–property correlations

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Abstract

Processing of commercial bioactive glasses in the form of scaffolds, fibers and coatings on metal implants is a major challenge due to their high crystallization tendency leading to loss of many desirable functionalities relevant to bone tissue engineering applications. In this context, this work focuses on develo** borosilicate bioactive glasses with improved thermal stability from the detailed understanding of composition–structure–property correlations. Structural studies through Raman and magic angle spinning nuclear magnetic resonance (MAS NMR) spectroscopy revealed the formation of a highly crosslinked network rich in B–O–Si bonds facilitating enhanced thermal stability (> 150 °C) for 17.96–35.92 mol% B2O3 containing glasses. These glasses also exhibit substantially improved in vitro biological properties such as biomineralization, cell proliferation, alkaline phosphatase (ALP) expression and antibacterial efficacy owing to predominance of B–O–Si and B–O–B bonds. However, more detailed data with pre-clinical studies are needed to confirm these observations, and for using them for specific applications.

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Acknowledgments

The authors would like to acknowledge the CSIR FBR research grant (MLP0108) and CSIR-HRDG Extramural Research GATE fellowship and DBT Ramalingaswami Re-Entry Fellowship (BT/RLF/Reentry/13/2016) of Government of India for financial support. Authors are also very much thankful to Dr. Vamsi Krishna Balla, Bioceramics and Coatings Division, CGCRI for his valuable suggestions on the manuscript. The authors thank Dr. Somoshree Sengupta, Bioceramics and Coatings Division, CGCRI for her help in cell culture.

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Authors and Affiliations

  1. Specialty Glass Division, CSIR-Central Glass & Ceramic Research Institute, 196, Raja S C Mullick Road, Kolkata, 700032, India

    Anustup Chakraborty, Sakthi Prasad & Kaushik Biswas

  2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, 201 002, India

    Anustup Chakraborty, Sakthi Prasad, Shashi Kant, P. K. Sinha, Amarnath R. Allu, Subhadip Bodhak & Kaushik Biswas

  3. Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, 700032, India

    Shashi Kant & Sucheta Tripathy

  4. Bioceramics and Coating Division, CSIR-Central Glass & Ceramic Research Institute, 196, Raja S C Mullick Road, Kolkata, 700032, India

    Rathina Vel & Subhadip Bodhak

  5. Energy Materials and Devices Division, CSIR-Central Glass & Ceramic Research Institute, 196, Raja S C Mullick Road, Kolkata, 700032, India

    Amarnath R. Allu

  6. Department of Physics, Dr. Harisingh Gour Central University, Sagar, Madhya Pradesh, 470003, India

    Krishna K. Dey

  7. Department of Zoology, Dr. Harisingh Gour Central University, Sagar, Madhya Pradesh, 470003, India

    Lekhan Lodhi

  8. Analytical Chemistry Group, CSIR-Central Glass & Ceramic Research Institute, Kolkata, 700032, India

    P. K. Sinha

  9. Physics Section, Mahila Maha Vidyalaya, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India

    Manasi Ghosh

Authors
  1. Anustup Chakraborty
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  2. Sakthi Prasad
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  3. Shashi Kant
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  4. Rathina Vel
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  5. Sucheta Tripathy
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  6. P. K. Sinha
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  7. Krishna K. Dey
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  8. Lekhan Lodhi
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  9. Manasi Ghosh
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  10. Amarnath R. Allu
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  11. Subhadip Bodhak
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  12. Kaushik Biswas
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Corresponding author

Correspondence to Kaushik Biswas.

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Chakraborty, A., Prasad, S., Kant, S. et al. Thermally stable bioactive borosilicate glasses: Composition–structure–property correlations. Journal of Materials Research 38, 2969–2985 (2023). https://doi.org/10.1557/s43578-023-01017-6

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