Abstract
Phytochemical investigation of Bauhinia acuruana Moric., Fabaceae, resulted in the isolation of sixteen constituents, including two new compounds 2′-hydroxy-2,3,5-trimethoxybibenzyl (1), (2R,3S)-2-(3,4′-dihydroxyphenyl)-5-methoxy-6-methylchroman-3,7-diol (2), together with fourteen known ones (3–16). The structures of the compounds were established by spectroscopic analysis including HR-ESIMS, 1D and 2D NMR data, followed by comparison with previously reported data from the literature. Compounds 1, 2, 6, 7, 8 and 9 were evaluated for their cytotoxicity, which turned out to be marginal in a panel of six human cancer cell lines.
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RWSG (PhD student) did the compound isolation procedure and contributed in compound identification by NMR and literature search. LMS, HCS, FEFS and ATAP contributed in carrying out the laboratory work, and interpretation of the spectroscopic data. MASL, AMCA, TLGL and RBF contributed in the interpretation of the spectroscopic data. GCCG and PBNS contributed to biological assays. FJTG contributed to plant collection and confection of herbarium. GMPS designed the study, supervised the laboratory work and wrote the manuscript. LMS contributed to critical reading of the manuscript. All the authors have read the final manuscript and approved the submission.
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Góis, R.W.S., de Sousa, L.M., da Silva, H.C. et al. Chemical constituents from Bauhinia acuruana and their cytotoxicity. Rev. Bras. Farmacogn. 27, 711–715 (2017). https://doi.org/10.1016/j.bjp.2017.09.002
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DOI: https://doi.org/10.1016/j.bjp.2017.09.002