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Antibacterial substances from Albizia myriophylla wood against cariogenic Streptococcus mutans

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Abstract

Albizia myriophylla has been used for long by Thai traditional healers as an important ingredient herb in Thai herbal formulas for caries. In this study, three flavonoids lupinifolin (6), 8-methoxy-7,3′,4′-trihydroxyflavone (7), and 7,8,3′,4′-tetrahydroxyflavone (8), a triterpenoid lupeol (3) as well as four sterols β-sitosterone (1), stigmasta-5,22-dien-3-one (2), β-sitosterol (4), and stigmasterol (5) were isolated from A. myriophylla wood. The antibacterial activity of these compounds against Streptococcus mutans ATCC 25175 was performed using broth microdilution method. All compounds exhibited antibacterial activity against S. mutans with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) ranging from 1–256 and 2–256 μg/ml, respectively. Among the isolated compounds, lupinifolin (6) was found to be the most potent with MIC and MBC of 1 and 2 μg/ml, respectively. Lupinifolin (6) also showed a strong activity against ten clinical isolates of S. mutans with MIC and MBC ranging from 0.25–2 and 0.5–8 μg/ml, respectively. These results reported the bioactive ingredients of A. myriophylla which support its ethnomedical claims as well. Lupinifolin (6) may have a potential to be a natural anticariogenic agent.

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Acknowledgments

This paper was supported by research funds from Prince of Songkla University, the Thailand Research Fund, and the Office of the Higher Education Commission (MRG5580107 and TTM5406815).

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Authors and Affiliations

  1. Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand

    Nantiya Joycharat, Sonesay Thammavong, Surasak Limsuwan & Sanan Subhadhirasakul

  2. Department of Microbiology, Faculty of Science, Prince of Songkla University, Songkhla, 90112, Thailand

    Sirilux Homlaead & Supayang Piyawan Voravuthikunchai

  3. Natural Products Research Center, Faculty of Science, Prince of Songkla University, Songkhla, 90112, Thailand

    Nantiya Joycharat, Surasak Limsuwan & Supayang Piyawan Voravuthikunchai

  4. Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand

    Boon-ek Yingyongnarongkul

  5. Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla, 90112, Thailand

    Sukanya Dej-adisai & Sanan Subhadhirasakul

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Joycharat, N., Thammavong, S., Limsuwan, S. et al. Antibacterial substances from Albizia myriophylla wood against cariogenic Streptococcus mutans . Arch. Pharm. Res. 36, 723–730 (2013). https://doi.org/10.1007/s12272-013-0085-7

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