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Current Management Options for Dyspnea in Cancer Patients

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Opinion statement

Dyspnea is one of the most frequent and distressing symptoms in patients with advanced cancer. As dyspnea deteriorates patients’ quality of life markedly and tends to worsen as the disease progresses, comprehensive assessment and timely treatment of the underlying etiologies are essential. International guidelines recommend various non-pharmacological and pharmacological management options. However, there is a scarcity of confirmatory clinical trials on cancer dyspnea, and the overall level of evidence is weak. Recently, observational and survey studies indicated a wide range of practice patterns of palliative care specialists, providing important insight into the real-world management of dyspnea. In this paper, we summarize current management options for dyspnea in cancer patients, highlight major controversies in the literature, and propose future research directions toward quality care for patients with dyspnea and their families.

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Funding

This work was supported in part by the JSPS KAKENHI Grant Number 21H02833.

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Authors and Affiliations

  1. Division of Palliative and Supportive Care, Seirei Mikatahara General Hospital, 3453 Mikatahara-cho, Kita-ku, Hamamatsu, 433-8558, Japan

    Masanori Mori MD & Tatsuya Morita MD

  2. Seirei Hospice, Seirei Mikatahara General Hospital, Hamamatsu, Japan

    Satoru Miwa MD

  3. Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan

    Tomoo Ikari MD, PhD

  4. College of Nursing Art and Science, University of Hyogo, Akashi, Japan

    Jun Kako RN, PhD

  5. Center for Psycho-oncology and Palliative Care, Nagoya City University Hospital, Nagoya, Japan

    Takaaki Hasegawa MD, PhD

  6. Division of Palliative Care, Konan Medical Center, Konan, Japan

    Ryo Matsunuma MD, PhD

  7. Department of Palliative Care, Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo, Japan

    Kozue Suzuki MD

  8. Department of Psychosomatic Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Japan

    Yoshinobu Matsuda MD

  9. Home Palliative Care Asunaro Clinic, Komaki, Japan

    Hiroaki Watanabe MD

  10. Department of Palliative Medicine, Kobe University Graduate School of Medicine, Kobe, Japan

    Takashi Yamaguchi MD, PhD

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  1. Masanori Mori MD
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Correspondence to Masanori Mori MD.

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Conflict of Interest

Dr. Takashi Yamaguchi received honoraria from Shionogi & Co., Ltd., Daiichi-Sankyo, and Hisamitsu Pharmaceutical Co., Inc. for the presentations.

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Mori, M., Miwa, S., Ikari, T. et al. Current Management Options for Dyspnea in Cancer Patients. Curr. Treat. Options in Oncol. 24, 565–579 (2023). https://doi.org/10.1007/s11864-023-01081-4

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