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Effect of heated humidified high-flow nasal cannula (HFNC) oxygen therapy in dyspnea patients with advanced cancer, a randomized controlled clinical trial

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Abstract

Purpose

Heated humidified high-flow nasal cannula (HFNC) oxygen therapy is one of the most important oxygen therapy methods, which are commonly applied to relieve dyspnea in advanced cancer patients. Our study aims to observe the efficacy and safety of HFNC oxygen therapy on dyspnea patients with advanced cancer and explore the clinical application.

Methods

Sixty subjects with advanced cancer requiring oxygen therapy from a grade 3, class A hospital in China were recruited and randomized (1:1) to traditional nasal catheter oxygen therapy or HFNC. Primary outcomes were dyspnea, oral dryness, and sleep condition, which were recorded after 72-h treatment. Secondary outcomes were heart rate (HR), respiration rate (RR), SpO2, PaO2, and PaCO2, which were recorded after 2, 6, 24, and 72 h treatment.

Results

Seventy-two hours after treatment, there were significant improvements in all primary outcomes (P < 0.001). PaO2 and RR were statistically changed 2 h after HFNC treatment (P < 0.001). PaCO2 and HR were statistically changed 24 h after HFNC treatment (P < 0.001).

Conclusion

HFNC oxygen therapy has good effect, high safety, and is easy to be accepted by dyspnea patients with advanced cancer. It can be used as the first choice of oxygen therapy for these patients and has broad clinical prospects.

Trial registration.

This work was retrospectively registered in the Chinese Clinical Trials Registry (ChiCTR2100049582) on August 4, 2021.

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Availability of data and material

All data can be available on https://www.chictr.org.cn/index.aspx.

Code availability

SPSS version 22.0 (SPSS Inc., Chicago, IL, USA).

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Funding

This work was supported by Qilu Hospital of Shandong University [2018-6].

Author information

Author notes

  1. Zhaoning Xu, **** Li are contributed equally to this work.

Authors and Affiliations

  1. Institute of Respiratory Monitoring and Support, Shandong University, **an, 250012, Shandong, China

    Zhaoning Xu

  2. School of Nursing and Rehabilitation, Shandong University, **an, 250012, Shandong, China

    Zhaoning Xu & **** Li

  3. School of Stomatology, Shandong University, **an, 250012, Shandong, China

    Chi Zhang

  4. Department of Pulmonary and Critical Care Medicine, Qilu Hospital, Shandong University, **an, 250012, Shandong, China

    Dedong Ma

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  1. Zhaoning Xu
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  2. **** Li
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Contributions

Conceptualization: ZX, PL; methodology: ZX, PL; formal analysis and investigation: ZX, PL, CZ; writing — original draft preparation: ZX, PL, CZ, DM; writing — review and editing: ZX, PL, CZ, DM; funding acquisition: DM; supervision: DM.

Corresponding author

Correspondence to Dedong Ma.

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All procedures performed in studies involving human participants were in accordance with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The trial was approved by the First Hospital of Zibo City in China Ethics Committee (No.2019016).

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Xu, Z., Li, P., Zhang, C. et al. Effect of heated humidified high-flow nasal cannula (HFNC) oxygen therapy in dyspnea patients with advanced cancer, a randomized controlled clinical trial. Support Care Cancer 30, 9093–9100 (2022). https://doi.org/10.1007/s00520-022-07330-w

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