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Immunotropic Properties of an Experimental Synthetic Selenium-Organic Compound

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied immunotropic properties of synthetic selenium-organic preparation 2,6-dipyridinium-9-selenabicyclo[3.3.1]nonyl dibromide (974zh). The experimental preparation reduced the cAMP/cGMP ratio, which indicated an increase in proliferative activity of cells of immunocompetent organs (thymus and spleen) in experimental animals. It was shown that 974zh intensified the immune response to Yersinia pestis EV thereby increasing the resistance to the plague agent.

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Authors and Affiliations

  1. Irkutsk Antiplague Research Institute, Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Irkutsk, Russia

    O. V. Yur’eva, V. I. Dubrovina, T. P. Starovoitova, T. A. Ivanova, T. T. Shkaruba & S. V. Balakhonov

  2. A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Division of the Russian Academy of Science, Irkutsk, Russia

    V. A. Potapov, M. V. Musalov & V. A. Yakimov

Authors
  1. O. V. Yur’eva
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  2. V. I. Dubrovina
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  3. V. A. Potapov
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  4. M. V. Musalov
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  5. T. P. Starovoitova
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  6. T. A. Ivanova
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  7. T. T. Shkaruba
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  8. V. A. Yakimov
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  9. S. V. Balakhonov
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Corresponding author

Correspondence to V. I. Dubrovina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 1, pp. 45-48, January, 2020

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Yur’eva, O.V., Dubrovina, V.I., Potapov, V.A. et al. Immunotropic Properties of an Experimental Synthetic Selenium-Organic Compound. Bull Exp Biol Med 169, 40–42 (2020). https://doi.org/10.1007/s10517-020-04819-4

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  • DOI: https://doi.org/10.1007/s10517-020-04819-4

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