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Effect of Synthetic Organoselenium Drug on the Degree of Pathological Changes in the Organs of White Mice Immunized with Tularemia and Brucellosis Vaccines

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of the organoselenium compound 2,6-dipyridinium-9-selenium-bicyclo[ 3,3,1]nonan dibromide (974zh) on the severity of pathological changes in the organs of experimental animals immunized with live tularemia and brucellosis vaccines. It was found that 974zh reduced reactogenicity of vaccines for experimental animals. Our findings indicate the prospects for further studies of the effects of 974zh on the functional state of experimental animals.

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Authors and Affiliations

  1. Irkutsk Research Anti-Plague Institute, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia

    O. V. Yurieva, V. I. Dubrovina, T. P. Starovoitova, T. A. Ivanova, A. V. Gromova, T. T. Shkaruba & S. V. Balakhonov

  2. A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Division of the Russian Academy of Science, Irkutsk, Russia

    V. A. Potapov & M. V. Musalov

Authors
  1. O. V. Yurieva
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  2. V. I. Dubrovina
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  3. V. A. Potapov
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  4. M. V. Musalov
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  5. T. P. Starovoitova
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  6. T. A. Ivanova
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  7. A. V. Gromova
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  8. T. T. Shkaruba
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  9. S. V. Balakhonov
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Corresponding author

Correspondence to V. I. Dubrovina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 7, pp. 76-79, July, 2019

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Yurieva, O.V., Dubrovina, V.I., Potapov, V.A. et al. Effect of Synthetic Organoselenium Drug on the Degree of Pathological Changes in the Organs of White Mice Immunized with Tularemia and Brucellosis Vaccines. Bull Exp Biol Med 168, 66–68 (2019). https://doi.org/10.1007/s10517-019-04648-0

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  • DOI: https://doi.org/10.1007/s10517-019-04648-0

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