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A Biomimetic Surface for Infection-resistance through Assembly of Metal-phenolic Networks

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Abstract

Despite the fact that numerous infection-resistant surfaces have been developed to prevent bacterial colonization and biofilm formation, develo** a stable, highly antibacterial and easily produced surface remains a technical challenge. As a crucial structural component of biofilm, extracellular DNA (eDNA) can facilitate initial bacterial adhesion, subsequent development, and final maturation. Inspired by the mechanistic pathways of natural enzymes (deoxyribonuclease), here we report a novel antibacterial surface by employing cerium (Ce(IV)) ion to mimic the DNA-cleavage ability of natural enzymes. In this process, the coordination chemistry of plant polyphenols and metal ions was exploited to create an in situ metal-phenolic film on substrate surfaces. Tannic acid (TA) works as an essential scaffold and Ce(IV) ion acts as both a cross-linker and a destructor of eDNA. The Ce(IV)-TA modified surface exhibited highly enhanced bacteria repellency and biofilm inhibition when compared with those of pristine or Fe(III)-TA modified samples. Moreover, the easily produced coatings showed high stability under physiological conditions and had nontoxicity to cells for prolonged periods of time. This as-prepared DNA-cleavage surface presents versatile and promising performances to combat biomaterial-associated infections.

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Acknowledgments

This work was financially supported by the Research Program Funds of Jilin University (Nos. 419080500665 and 451170301076), and the Natural Science Foundation of Shandong Province (No. ZR2015EM036).

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Authors and Affiliations

  1. Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun, 130022, China

    Ru-Jian Jiang, Li-Mei Tian, Lu-Quan Ren & Jie Zhao

  2. School of Chemistry and Chemical Engineering, Yantai University, Yantai, 264005, China

    Ru-Jian Jiang, Shi-Ai Xu & Zhi-Rong **n

  3. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China

    Shun-Jie Yan, Shi-Fang Luan & **g-Hua Yin

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  1. Ru-Jian Jiang
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  2. Shun-Jie Yan
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  5. Zhi-Rong **n
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  8. Lu-Quan Ren
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  9. Jie Zhao
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Correspondence to Zhi-Rong **n or Jie Zhao.

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Jiang, RJ., Yan, SJ., Tian, LM. et al. A Biomimetic Surface for Infection-resistance through Assembly of Metal-phenolic Networks. Chin J Polym Sci 36, 576–583 (2018). https://doi.org/10.1007/s10118-018-2032-z

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  • DOI: https://doi.org/10.1007/s10118-018-2032-z

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