Abstract
Electroosmosis pumps (EOPs) have been widely used for manipulating small amounts of reagents for chemical and biological analysis. Traditionally, a high-voltage DC has to be applied in order to achieve the required flow rate. One alternative is to use low AC voltage. Here we propose another solution, which, instead of using a high-voltage DC or low AC voltage, adds a low-voltage DC to an array of electrodes. This design of EOP is called a relaying EOP or cascade EOP. In this study, we intend to push the limit of the low-voltage further down to 2 V by patterning a dense electrode array in a straight microchannel. Two patterns of interdigitated electrodes, symmetric with equal size electrodes and asymmetric with unequal size electrodes, are proposed. Simulations are performed to optimize the distribution and geometrical parameters of the electrode array in order to achieve the maximum flow rate. The proposed low-voltage DC electroosmosis pump shows an advantage in integrating EOP into portable Lab-on-a-chip devices. In addition, the low-voltage DC EOP shows a good promise for in vivo biomedical applications such as drug delivery.
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References
Andersson H, Van den Berg A (2004) Microtechnologies and nanotechnologies for single-cell analysis. Curr Opin Biotechnol 15(1):44–49. doi:10.1016/j.copbio.2004.01.004
Chen X, Kis A, Zettl A, Bertozzi CR (2007) A cell nanoinjector based on carbon nanotubes. Proc Natl Acad Sci USA 104:8218–8222. doi:10.1073/pnas.0700567104
Dittrich PS, Tachikawa K, Manz A (2006) Micro total analysis systems. Latest advancements and trends. Anal Chem 78:3887–3908. doi:10.1021/ac0605602
Ferrance JP et al (2003) Developments toward a complete micro-total analysis system for Duchenne muscular dystrophy diagnosis. Anal Chim Acta 500(1–2):223–236. doi:10.1016/j.aca.2003.08.067
Garcia-Sanchez P, Ramos A (2006) Experiments on AC electrokinetic pum** of liquids using arrays of microelectrodes. IEEE Trans Dielectr Electr Insul 13(3):670–677. doi:10.1109/TDEI.2006.1657983
Green NG, Ramos A, González A, Morgan H, Castellanos A (2000) Fluid flow induced by nonuniform ac electric fields in electrolytes on microelectrodes. I. Experimental measurements. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics 61:4011–4018. doi:10.1103/PhysRevE.61.4011
Han SW, Nakamura C, Obataya I, Nakamura N, Miyake J (2005) A molecular delivery system by using AFM and nanoneedle. Biosens Bioelectron 20(10):2120–2125. doi: 10.1016/j.bios.2004.08.023; http://www.comsol.com/
Kwak HS, Ernest FH (2005) Timescales for relaxation to Boltzmann equilibrium in nanopores. J Colloid Interface Sci 284:753–758. doi:10.1016/j.jcis.2004.10.074
Lagally ET, Medintz I, Mathies RA (2001) Single-molecule DNA amplification and analysis in an integrated microfluidic device. Anal Chem 73:565–570. doi:10.1021/ac001026b
Laser DJ, Santiago JG (2004) A review of micropumps. J Micromech Microeng 14(6):35–64. doi:10.1088/0960-1317/14/6/R01
Lee SJ, Lee SY (2004) Micro total analysis system (μ-TAS) in biotechnology. Appl Microbiol Biotechnol 64(3):289–299. doi:10.1007/s00253-003-1515-0
Masliyah JH, Bhattacharjee S (2006) Electrokinetic and colloid transport phenomena. Wiley, Hoboken
Reyes DR, Iossifidis D, Auroux PA, Manz A (2002) Micro total analysis systems. 1. Introduction, theory, and technology. Anal Chem 74:2623–2636. doi:10.1021/ac0202435
Sun T, Morgan H, Green NG (2007) Analytical solutions of ac electrokinetics in interdigitated electrode arrays: electric field, dielectrophoretic and traveling-wave dielectrophoretic forces. Phys Rev E 76(4):046610-1–046610-18
Urbanski JP et al (2006) Fast ac electro-osmotic micropumps with nonplanar electrodes. Appl Phys Lett 89:143508. doi:10.1063/1.2358823
Van de Ven T (1989) Colloidal hydrodynamics. Academic Press, London
Zeng S, Chenb CH, Mikkelsen JC, Santiagob JG (2001) Fabrication and characterization of electroosmotic micropumps. Sens Actuators B Chem 79(2–3):107–114. doi:10.1016/S0925-4005(01)00855-3
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The authors gratefully acknowledge financial support of this research from Natural Science and Engineering Research Council of Canada (NSERC) and The Shared Hierarchial Academic Research Computing Network (SHARCNET) of Canada.
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Guo, Q., Liu, Y., Wu, X. et al. Design of a relaying electroosmosis pump driven by low-voltage DC. Microsyst Technol 15, 1009–1015 (2009). https://doi.org/10.1007/s00542-009-0840-3
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DOI: https://doi.org/10.1007/s00542-009-0840-3