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A meta-analysis on XRCC1 and XRCC3 polymorphisms and colorectal cancer risk

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Abstract

Purpose

Studies on polymorphism of X-ray repair cross-complementing group 1 (XRCC1), group 3 (XRCC3), and colorectal cancer risk are inconclusive. The purpose of this study is to evaluate the role of XRCC1 R399Q, R194W, and XRCC3 T241M genotypes in colorectal cancer susceptibility.

Methods

We performed a meta-analysis on all available studies that provided 3,514/4,686 cases/controls for R399Q, 2,767/3,907 cases/controls for R194W and 3,183/3,926 cases/controls for T241M.

Results

Overall, no apparent effects of 194 W allele compared to 194R on colorectal cancer risk were found in all subjects and subgroups (Asians and Caucasians). Insignificant effects were also found under other genetic contrasts (homologous contrast, dominant model, and recessive model). The same pattern of results was produced in T241M polymorphism. The 399Q allele compared to 399R showed no significant association with colorectal cancer risk in all subjects and subgroups. However, protective effects of 399QQ genotype were observed under recessive model (QQ/QR + RR) [P = 0.02, OR = 0.84, 95% CI (0.72, 0.97)] and homozygote contrast (QQ/RR) [P = 0.01, OR = 0.81; 95% CI (0.69, 0.95)] in all subjects.

Conclusion

Results suggested that 399Q allele might act as a recessive allele in its association with colorectal cancer.

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Authors and Affiliations

  1. Department of Colorectal Surgery, Cancer Hospital, Fudan University, 270 Dong An Road, Shanghai, 200032, China

    Zheng Jiang, Ye Xu & Sanjun Cai

  2. Laboratory of Medical Genetics, Harbin Medical University, 194 XueFu Road, Harbin, 150081, China

    Chunxiang Li

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  1. Zheng Jiang
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Correspondence to Sanjun Cai.

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Fig. S1

Allele contrast under FEs model for R399Q in all subjects after one study [18] was excluded (GIF 137 kb)

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Jiang, Z., Li, C., Xu, Y. et al. A meta-analysis on XRCC1 and XRCC3 polymorphisms and colorectal cancer risk. Int J Colorectal Dis 25, 169–180 (2010). https://doi.org/10.1007/s00384-009-0817-9

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