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A pure nanoICG-based homogeneous lipiodol formulation: toward precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

A Correction to this article was published on 12 May 2022

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Abstract

Purpose

To surmount the critical issues of indocyanine green (ICG), and thus achieving a precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization.

Methods

In this study, a facile and green pure-nanomedicine formulation technology is developed to construct carrier-free indocyanine green nanoparticles (nanoICG), and which subsequently dispersed into lipiodol via a super-stable homogeneous lipiodol formulation technology (SHIFT nanoICG) for transcatheter arterial embolization combined near-infrared fluorescence-guided precise hepatectomy.

Results

SHIFT nanoICG integrates excellent anti-photobleaching capacity, great optical imaging property, and specific tumoral deposition to recognize tumor regions, featuring entire-process enduring fluorescent-guided precise hepatectomy, especially in resection of the indiscoverable satellite lesions (0.6 mm × 0.4 mm) in rabbit bearing VX2 orthotopic hepatocellular carcinoma models.

Conclusion

Such a simple and effective strategy provides a promising avenue to address the clinical issue of clinical hepatectomy and has excellent potential for a translational pipeline.

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Funding

This work was supported by the Major State Basic Research Development Program of China (2017YFA0205201), the National Natural Science Foundation of China (81925019, 81422023, 81603015, 81871404, and U1705281), the Fundamental Research Funds for the Central Universities (20720190088, 20720200019, and 2020Y4003), China Postdoctoral Science Foundation (2021M702739), the Science and Technology Project of **amen municipal Bureau of Science and Technology (3502Z20194044), and the Program for New Century Excellent Talents in University, China (NCET-13–0502).

Author information

Author notes

  1. Y. Zhang, H. Cheng, H. Chen, and P. Xu contributed equally to this work.

Authors and Affiliations

  1. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, **amen University, **amen, 361102, China

    Yang Zhang, Hongwei Cheng, Hu Chen, En Ren, Yonghe Jiang, Dengfeng Li, **ng Gao, Yating Zheng, Pan He, Huirong Lin, Gan Lin, Chengchao Chu, **gsong Mao & Gang Liu

  2. Department of Radiology, **ang’an Hospital of **amen University, **amen, 361102, China

    Hu Chen & **gsong Mao

  3. Fujian Provincial Key Laboratory of Biochemical Technology, Institute of Biomaterials and Tissue Engineering, Huaqiao University, **amen, 361021, China

    Peiyao Xu, Biaoqi Chen & Aizheng Chen

  4. Amoy Hopeful Biotechnology Co., Ltd, **amen, 361027, China

    Chengchao Chu

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  1. Yang Zhang
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Contributions

Y. Z. and G. Liu conceived and designed the experiments. Y. Z., H. Cheng, H. Chen, P. X., E. R., Y. J., X.G., D.L., J. M., and Y. Z. performed the experiments. Y. Z., B.-Q. C., P. H., H. L., and A. C. analyzed the results. Y. Z., H. Cheng, G. Lin, C. C., J. M., and G. Liu wrote the manuscript. G. Liu supervised the entire project.

Corresponding authors

Correspondence to Chengchao Chu, **gsong Mao or Gang Liu.

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Zhang, Y., Cheng, H., Chen, H. et al. A pure nanoICG-based homogeneous lipiodol formulation: toward precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization. Eur J Nucl Med Mol Imaging 49, 2605–2617 (2022). https://doi.org/10.1007/s00259-021-05654-z

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