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Synthesis and cytotoxic activity of genistein derivatives

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Abstract

A series of genistein derivatives was prepared and tested in vitro against leukocythemia (HL-60), colorectal adenocarcinoma (HT-29), and human gastric adenocarcinoma (SGC-7901) cell lines. Among these derivatives, 4′,5-di-n-octoxy-7-gem-difluoromethylenegenistein, 9f, had the strongest activity against HL-60, HT-29, and SGC-7901 cells.

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Acknowledgments

This research was supported by the Key Project of the Chinese Ministry of Education (No. 20809), Scientific Research Fund of Hunan Provincial Education Department (No. 07B065), Science and Technology Bureau of Hunan Province (No. 2007FJ4155), and Hunan Provincial Natural Science Foundation (No. 07JJ6157).

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Authors and Affiliations

  1. Institute of Pharmacy and Pharmacology, Nanhua University, Hengyang, 421001, People’s Republic of China

    **ng Zheng, Xu Yao, Yunmei Liu, Zitong Zheng & Duanfang Liao

  2. Medical College, Hunan Normal University, Hunan Changsha, 410006, People’s Republic of China

    Jianguo Cao

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  1. **ng Zheng
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  2. Xu Yao
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  3. Yunmei Liu
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  4. Zitong Zheng
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  5. Jianguo Cao
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  6. Duanfang Liao
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Correspondence to **ng Zheng.

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Zheng, X., Yao, X., Liu, Y. et al. Synthesis and cytotoxic activity of genistein derivatives. Med Chem Res 19, 1296–1306 (2010). https://doi.org/10.1007/s00044-009-9271-z

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  • DOI: https://doi.org/10.1007/s00044-009-9271-z

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