SpringerLink
Log in

Participation of mitochondria in calcium signalling in the exocrine pancreas

Participación de la mitocondria en las señales de calcio en el páncreas exocrino

  • Minireviews
  • Published:
Journal of Physiology and Biochemistry Aims and scope Submit manuscript

Abstract

This minireview is an attempt to put together some of the recent advances regarding the implications of mitochondria in Ca2+ homeostasis. Although the main role of this cytoplasmic organelle is ATP supply to the cell, during the past years strong evidence has been accumulated supporting an active role of these organelles in Ca2+ handling by the cell. The discovery of mitochondrial specific fluorescent dyes has permitted the study of these organelles within living cells. Due to its ubiquitous localisation within the cytosol, mitochondria would play an important role in the modulation of the subcellular patterns of Ca2+ signalling, and therefore would act as modulators of Ca2+-dependent cellular processes.

Resumen

Esta revisión intenta reunir los avances recientes que se han realizado en torno a las implicaciones de la mitocondria en la homeostasis del ion Ca2+. Aunque la principal función de este orgánulo citoplasmático es el aporte de energía para la célula, durante los últimos años se han encontrado evidencias que apoyan una función activa de la mitocondria en la regulación de los niveles de Ca2+ libre citosólico por la célula. El descubrimiento de indicadores fluorescentes específicos para la mitocondria ha permitido el estudio de la función de estos orgánulos en la célula intacta. Debido a su ubiquidad en el citoplasma de la célula, la mitocondria desempeñaría un importante papel como modulador de los patrones intracelulares de Ca2+ y, por tanto, como regulador de aquellos procesos celulares dependientes de Ca2+

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (France)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Babcock, D. F., Herrington, J., Goodwin, P. C., Park, Y. B. and Hille, B. (1997):J. Cell Biol.,136, 833–844.

    Article  CAS  PubMed  Google Scholar 

  2. Boitier, E., Rea, R. and Duchen, M. R. (1999):J. Cell Biol.,145, 795–808.

    Article  CAS  PubMed  Google Scholar 

  3. Chacon, E., Ohata, H., Harper, I. S., Trollinger, D. R., Herman, B. and Lemasters, J. J. (1996):FEBS Letters,382, 31–36.

    Article  CAS  PubMed  Google Scholar 

  4. Crompton, M., Moser, R., Ludi, H. and Carafoli, E. (1978):Eur. J. Biochem.,82, 25–31.

    Article  CAS  PubMed  Google Scholar 

  5. Csordás, G., Thomas, A. P. and Hajnóczky, G. (1999):EMBO J.,18, 96–108.

    Article  PubMed  Google Scholar 

  6. Denton, R. M. and McCormack, J. G. (1983):FEBS Lett.,199, 1–8.

    Google Scholar 

  7. González, A., Pfeiffer, F., Schmid, A. and Schulz, I. (1998):Am. J. Physiol.,275, C810-C817.

    PubMed  Google Scholar 

  8. González, A., Schmid, A., Sternfeld, L., Krause, E., Salido, G. M. and Schulz, I. (1999):Biochem. Biophys. Res. Commun.,261, 726–733.

    Article  PubMed  Google Scholar 

  9. González, A., Schulz, I. and Schmid, A. (2000):J. Biol. Chem.,275, 38680–38686.

    Article  PubMed  Google Scholar 

  10. Gorelick, F. S. and Jamieson, J. D. (1994): In “Physiology of the gastrointestinal tract”, 3rd ed. (L. R. Johnson, ed.). Raven Press, New York, pp. 1353–1376.

    Google Scholar 

  11. Gunter, T. E. and Pfeiffer, D. R. (1990):Am. J. Physiol.,258, C755-C786.

    CAS  PubMed  Google Scholar 

  12. Gurney, A. M., Drummond, R. M. and Fay, F. S. (2000):Cell Calcium,27, 339–351.

    Article  CAS  PubMed  Google Scholar 

  13. Hajnóczky G., Robb-Gaspers, L. D., Seit, M. B. and Thomas, A. P. (1995):Cell,82, 415–424.

    Article  PubMed  Google Scholar 

  14. Hajnóczky, G., Hager, R. and Thomas, A. (1999):J. Biol. Chem.,274, 14157–14162.

    Article  PubMed  Google Scholar 

  15. Haughland, R. P. (1999): In “Handbook of fluorescent probes and research chemicals”, 6th ed. (M. T. Z. Spence, ed.). Molecular Probes Inc., Leiden, pp. 266–273.

    Google Scholar 

  16. Hoth, M., Fanger, C. M. and Lewis, R.S. (1997):J. Cell Biol,137, 633–648.

    Article  CAS  PubMed  Google Scholar 

  17. Ischas, F., Jouaville, L. S. and Mazat, J.-P. (1997):Cell,89, 1145–1153.

    Article  Google Scholar 

  18. Jouaville, L. S., Ischas, F., Holmuhamedov, E. L., Camacho, P. and Lechleiter, J. D. (1995):Nature,377, 348–341.

    Article  Google Scholar 

  19. Jouaville L. S., Ischas F. and Mazat J. P. (1998):Mol. Cell Biochem.,184, 371–376.

    Article  CAS  PubMed  Google Scholar 

  20. Kaftan, E. J., Xu, T., Abercrombie, R. F. and Hille, B. (2000):J. Biol. Chem.,275, 25465–25470.

    Article  CAS  PubMed  Google Scholar 

  21. Kasai, H. and Augustine, G. J. (1990):Nature,348, 735–738.

    Article  CAS  PubMed  Google Scholar 

  22. Lawrie, A. M., Rizzuto, R., Pozzan, T. and Simpson, A. W. (1996):J. Biol. Chem.,271, 10753–10759.

    Article  CAS  PubMed  Google Scholar 

  23. Monteith, G. R. and Blaustein, M. P. (1999):Am. J. Physiol.,276, C1193-C1204.

    CAS  PubMed  Google Scholar 

  24. Nathanson, M. H., Padfield, P. J., O’Sullivan, A. J., Burgstahler, A. D. and Jamieson, J. D. (1992):J. Biol. Chem.,267, 18118–18121.

    CAS  PubMed  Google Scholar 

  25. Nitschke, R., Wilhem, S., Borlinghaus, R., Leipziger, J., Bindels, R. and Greger, R. (1997):Pflügers Arch.,433, 653–663.

    Article  CAS  PubMed  Google Scholar 

  26. Pacher, P., Csordás, G., Schneider, T. G. and Hajnóczky, G. (2000):J. Physiol.,529, 553–564.

    Article  CAS  PubMed  Google Scholar 

  27. Park, M. K., Ashby, M. C., Erdemli, G., Petersen, O. H. and Tepikin, A. V. (2001):EMBO J.,20, 1863–1874.

    Article  CAS  PubMed  Google Scholar 

  28. Pfeiffer, F., Sternfeld, L., Schmid, A. and Schulz, I. (1998):Am. J. Physiol.,274, C663-C672.

    CAS  PubMed  Google Scholar 

  29. Ricken, S., Leipziger, J., Greger, R. and Nitschke, R. (1998):J. Biol. Chem.,273, 34961–34969.

    Article  CAS  PubMed  Google Scholar 

  30. Rizzuto, R., Simpson, A. W. M., Brini, M. and Pozzan, T. (1992):Nature,358, 325–328.

    Article  CAS  PubMed  Google Scholar 

  31. Rizzuto, R., Brini, M., Murgia, M. and Pozzan, T. (1993):Science,262, 744–747.

    Article  CAS  PubMed  Google Scholar 

  32. Rizzuto, R., Bastianutto, C., Brini, M., Murgia, M. and Pozzan, T. (1994):J. Cell Biol.,126, 1183–1194.

    Article  CAS  PubMed  Google Scholar 

  33. Rizzuto, R., Pinto, P., Carrington, W., Fay, F. S., Fogarty, K. E., Lifshitz, L. M., Tuft, R. A. and Pozzan, T. (1998):Science,280, 1763–1766.

    Article  CAS  PubMed  Google Scholar 

  34. Robb-Gaspers, L. D., Burnett, P., Rutter, G. A., Denton, R. M., Rizzuto, R. and Thomas, A. P. (1998):EMBO J.,17, 4987–5000.

    Article  CAS  PubMed  Google Scholar 

  35. Selivanov, V. A., Ischas, F., Holmuhamedov, E. L., Jouaville, L. S., Evtodienko, Y. V. and Mazat, J. P. (1998):Biophys. Chem.,72, 111–121.

    Article  CAS  PubMed  Google Scholar 

  36. Simpson, P. B. and Russel, J. T. (1996):J. Biol. Chem.,271, 33493–33501.

    Article  CAS  PubMed  Google Scholar 

  37. Simpson, P. B. and Russell, J. T. (1998):J. Physiol.,508, 413–426.

    Article  CAS  PubMed  Google Scholar 

  38. Straub, S. V., Giovannucci, D. R. and Yule, I. D. (2000):J. Gen. Physiol.,116, 547–560.

    Article  CAS  PubMed  Google Scholar 

  39. Streb, H., Irvine, R. F., Berridge, M. J. and Schulz, I. (1983):Nature,306, 67–69.

    Article  CAS  PubMed  Google Scholar 

  40. Szalai, G., Csordás, G., Hantash, B. M., Thomas, A. P. and Hajnóczky, G. (2000):J. Biol. Chem.,275, 15305–15313.

    Article  CAS  PubMed  Google Scholar 

  41. Thorn, P., Lawrie, A. M., Smith, P. M., Gallacher, D. V. and Petersen, O. H. (1993):Cell,74, 661–668.

    Article  CAS  PubMed  Google Scholar 

  42. Tinel, H., Cancela, J. M., Mogami, H., Gerasimenko, J. V., Gerasimenko, O. V., Tepikin, A. V. and Petersen, O. H. (1999):EMBO J.,18, 4999–5008.

    Article  CAS  PubMed  Google Scholar 

  43. Toescu, E. C., Gardner, J. M. and Petersen, O. H. (1993):Biochem. Biophys. Res Commun.,192, 854–859.

    Article  CAS  PubMed  Google Scholar 

  44. Wood, P. G. and Gillespie, J. I. (1998):Biochem. Biophys. Res. Commun.,246, 543–548.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, University of Extremadura, Faculty of Veterinary Sciences, 10071, Cáceres, Spain

    A. González & G. M. Salido

Authors
  1. A. González
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. M. Salido
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G. M. Salido.

Rights and permissions

Reprints and permissions

About this article

Cite this article

González, A., Salido, G.M. Participation of mitochondria in calcium signalling in the exocrine pancreas. J. Physiol. Biochem. 57, 331–339 (2001). https://doi.org/10.1007/BF03179827

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03179827

Key words

Palabras clave

Search

Navigation