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Beta Cell Store-Operated Ion Channels

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Islets of Langerhans, 2. ed.

Abstract

Signaling molecules produced in the pancreatic β-cell following mitochondrial oxidation of glycolytic intermediate metabolites and oxidative phosphorylation trigger Ca2+-dependent signaling pathways that regulate insulin exocytosis. Much is known about ATP-sensitive K+ and voltage-gated Ca2+ currents that contribute to Ca2+-dependent signal transduction in β-cells and insulin secretion, but relatively little is known about other Ca2+ channels that regulate β-cell Ca2+ signaling dynamics and insulin secretion. In a wide range of eukaryotic cells, store-operated Ca2+ entry (SOCE) plays a critical role regulating spatial and temporal changes in cytoplasmic Ca2+ concentration, endoplasmic reticulum (ER) Ca2+ homeostasis, gene expression, protein biosynthesis, and cell viability. Although SOCE has been proposed to play important roles in β-cell Ca2+ signaling and insulin secretion, the underlying molecular mechanisms remain undefined. In this chapter, we provide both an overview of our current understanding of ionic currents regulated by ER Ca2+ stores in insulin-secreting cells and a review of studies in other cell systems that have identified the molecular basis and regulation of SOCE.

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Acknowledgments

Research in the authors’ laboratories was supported by the American Diabetes Association Research Award 1-12-BS-109 (CAL) and by the National Institutes of Health R01 grants DK074966 and DK092616 (MWR).

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Authors and Affiliations

  1. Department of Medicine, State University of New York Upstate Medical University Syracuse, 505 Irving Ave., Syracuse, NY, USA

    Colin A. Leech (Associate Professor), Dr. Richard F. Kopp & Prof. Michael Wm. Roe

  2. Department of Medicine, University of Chicago, Chicago, IL, USA

    Prof. Louis H. Philipson

Authors
  1. Colin A. Leech
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  2. Dr. Richard F. Kopp
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  3. Prof. Louis H. Philipson
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  4. Prof. Michael Wm. Roe
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Corresponding author

Correspondence to Michael Wm. Roe .

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Editors and Affiliations

  1. Södersjukhuset, Karolinska Institutet Dept. Clinical Research & Education, Stockholm, Sweden

    Md. Shahidul Islam

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Leech, C.A., Kopp, R.F., Philipson, L.H., Roe, M.W. (2014). Beta Cell Store-Operated Ion Channels . In: Islam, M. (eds) Islets of Langerhans, 2. ed.. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6884-0_40-2

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  • DOI: https://doi.org/10.1007/978-94-007-6884-0_40-2

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  • Online ISBN: 978-94-007-6884-0

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