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Serologically atypical adenovirus strains of subgenus D are different in their genome from the respective prototypes

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Abstract

Seven adenovirus strains of subgenus D, related to adenovirus types 8, 10, 13, 19, 23, 24 and 26, but atypical in their serological reactions or in hemagglutinin properties, were characterized by neutralization and hemagglutination-inhibition. DNA restriction analysis with five endonucleases showed that each of the strains was strikingly different from the respective prototype.

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References

  1. Adrian Th, Bastian B, Benoist W, Hierholzer JC, Wigand R (1985) Characterization of adenovirus 15/H9 itermediate strains. Intervirology 23:15–22

    Google Scholar 

  2. Adrian Th, Heinrich W (1986) COMAP: a comigrating analysis program for estimating the relationship of adenoviruses on the genome level. Nucleic Acids Res 14:559–565

    Google Scholar 

  3. Adrian Th, Wadell G, Hierholzer JC, Wigand R (1986) DNA restriction analysis of adenovirus prototypes 1 to 41. Arch Virol 91:277–290

    Google Scholar 

  4. Blacklow NR, Hoggan MD, Austin JB, Rowe WP (1969) Observations on two new adenovirus serotypes with unusual antigenic characteristics. Am J Epidemiol 90:501–505

    Google Scholar 

  5. Brown M, Petric M, Middleton PJ (1984) Silver staining of DNA restriction fragments for the rapid identification of adenovirus isolates: Application during nosocomial outbreaks. J Virol Methods 9:87–98

    Google Scholar 

  6. De Jong JC, Wigand R, Adrian Th, Hierholzer JC, Kapsenberg JG, Muzerie CJ, Wermenbol AG (1984) Adenovirus 38: a new human adenovirus species of subgenus D. Intervirology 22:164–169

    Google Scholar 

  7. Fujii SI, Nakazono N, Sawada H, Ishii K, Kato M, Aoki K, Ohtsuka H, Fu**aga K (1983) Restriction endonuclease cleavage analysis of adenovirus type 8: Two new subtypes from patients with epidemic keratoconjunctivitis in Sapporo, Japan. Jap J Med Sci Biol 36:307–313

    Google Scholar 

  8. Hierholzer JC (1973) Further subgrou** of the human adenoviruses by differential hemagglutination. J infect Dis 128:541–550

    Google Scholar 

  9. Kemp MC, Hierholzer JC, Cabradilla CP, Obijeski JF (1983) The changing etiology of epidemic keratoconjunctivities: antigenic and restriction enzyme analyses of adenovirus types 19 and 37 isolated over a ten year period. J infect Dis 148:24–33

    Google Scholar 

  10. Nötzel R, Adrian Th, Wigand R, Wadell G (1985) Characterization of hemagglutinin variant strains of adenovirus 15 and 9. Arch Virol 85:171–174

    Google Scholar 

  11. Pettersson U (1984) Structural and nonstructural adenovirus proteins. In Ginsberg HS (ed) The adenoviruses. Plenum, New York, pp 205–270

    Google Scholar 

  12. Rowe WP, Hartley JW, Huebner RJ (1958) Serotype composition of the adenovirus group. Proc Soc Exp Biol Med 97:465–470

    Google Scholar 

  13. Wadell G (1984) Molecular epidemiology of adenoviruses. Curr Top Microbiol Immunol 110:191–220

    Google Scholar 

  14. Wadell G, De Jong JC (1980) Restriction endonucleases in identification of a genome type of adenovirus 19 associated with keratoconjunctivities. Infect Immun 27:292–296

    Google Scholar 

  15. Wadell G, Varsanyi T, Lord A, Sutton RNP (1980) Epidemic outbreaks of adenovirus 7 with special reference to the pathogenicity of adenovirus genome type 7b. Am J Epidemiol 112:619–628

    Google Scholar 

  16. Wigand R (1968) Serologische Beziehungen der Adenoviren der Gruppe II. Arch ges Virusforsch 23:40–47

    Google Scholar 

  17. Wigand R, Adrian Th (1986) Classification and epidemiology of adenoviruses. In: Doerfler W (ed) Adenovirus DNA. The viral genome and its expression. Martinus Nijhoff, Boston Dordrecht Lancaster, pp 409–441

    Google Scholar 

  18. Wigand R, Bartha A, Dreizin RS, Esche H, Ginsberg HS, Green M, Hierholzer JC, Kalter SS, McFerran JB, Pettersson U, Russell WC, Wadell C (1982) Adenoviridae: Second report. Intervirology 18:169–176

    Google Scholar 

  19. Wigand R, Bauer H (1964) Über den cytopathogenen Effekt der Adenoviren des Menschen. Arch Virusforsch 14:674–682

    Google Scholar 

  20. Wigand R, Fliedner D (1968) Serologically intermediate adenovirus strains: a regular feature of group II adenoviruses. Arch Virusforsch 24:245–256

    Google Scholar 

  21. Wigand R, Gelderblom H, Özel M, Distler H, Adrian Th (1983) Characteristics of Mastadenovirus h 8, the causative agent of epidemic keratoconjunctivitis. Arch Virol 76:307–319

    Google Scholar 

  22. Wigand R, Keller D, Werling I (1982) Immunological relationship among human adenoviruses of subgenus D. Arch Virol 72:199–209

    Google Scholar 

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Aided by grants from the following institutions: Bundesministerium für Jugend, Familie, Frauen und Gesundheit, FRG; Fördererverein der Deutschen Vereinigung zur Bekämpfung der Viruskrankheiten e. V., München, FRG; Deutsche Forschungsgemeinschaft (Wi 3/21)

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Adrian, T., Best, B. & Wigand, R. Serologically atypical adenovirus strains of subgenus D are different in their genome from the respective prototypes. Med Microbiol Immunol 176, 217–224 (1987). https://doi.org/10.1007/BF00196689

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  • DOI: https://doi.org/10.1007/BF00196689

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