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Detectability of cold tumors by xSPECT bone technology compared with hot tumors: a supine phantom study
Detecting cold as well as hot tumors is vital for interpreting bone tumors on single-photon emission computed tomography (SPECT) images. This study...
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Feasibility of ultra-high-speed acquisition in xSPECT bone algorithm: a phantom study with advanced bone SPECT-specific phantom
ObjectiveAlthough xSPECT Bone (xB) provides quantitative single-photon emission computed tomography (SPECT) high-resolution images, patients’ burden...
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Impact of metal implants on xSPECT/CT Bone reconstruction: the “shining metal artefact”
BackgroundNovel reconstruction algorithms, such as xSPECT Bone, are gaining more and more importance in Nuclear Medicine. With xSPECT Bone, the...
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Phantom and clinical evaluation of bone SPECT/CT image reconstruction with xSPECT algorithm
BackgroundTwo novel methods of image reconstruction, xSPECT Quant (xQ) and xSPECT Bone (xB), that use an ordered subset conjugate gradient minimizer...
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Effect of kilovoltage and quality reference mAs on CT-based attenuation correction in 177Lu SPECT/CT imaging: a phantom study
IntroductionCT-based attenuation correction (CT-AC) plays a major role in accurate activity quantification by SPECT/CT imaging. However, the effect...
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Quantitative single photon emission computed tomography derived standardized uptake values on 99mTc-PYP scan in patients with suspected ATTR cardiac amyloidosis
Technetium-99 pyrophosphate scintigraphy (99mTc-PYP) provides qualitative and semiquantitative diagnosis of ATTR cardiac amyloidosis (ATTR-CA) using...
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Myocardial perfusion imaging with retrospective gating and integrated correction of attenuation, scatter, respiration, motion, and arrhythmia
BackgroundAbsolute quantitative myocardial perfusion SPECT requires addressing of aleatory and epistemic uncertainties in conjunction with providing...
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Accuracy comparison of various quantitative [99mTc]Tc-DPD SPECT/CT reconstruction techniques in patients with symptomatic hip and knee joint prostheses
BackgroundThere is a need for better diagnostic tools that identify loose total hip and knee arthroplasties. Here, we present the accuracy of...
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Inter-rater and intra-rater agreement of [99mTc]-labelled NM-01, a single-domain programmed death-ligand 1 (PD-L1) antibody, using quantitative SPECT/CT in non-small cell lung cancer
BackgroundImmune checkpoint inhibitors, including those against programmed cell death protein-1 (PD-1) or its ligand (PD-L1), are routinely used to...
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Transthyretin amyloid cardiomyopathy disease burden quantified using 99mTc-pyrophosphate SPECT/CT: volumetric parameters versus SUVmax ratio at 1 and 3 hours
BackgroundVarious parameters derived from technetium-99m pyrophosphate ( 99m Tc-PYP) single-photon emission computed tomography (SPECT) correlate with...
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The clinical value of xSPECT/CT Bone versus SPECT/CT. A prospective comparison of 200 scans
PurposeTo prospectively evaluate the clinical utility of xSPECT/CT Bone, a new reconstruction algorithm for single photon emission tomography...
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Common Variants and Pitfalls: Paget’s Disease
Paget’s disease is a common disorder causing focal areas of increased and disorganized bone turnover. Its appearance on imaging can be mistaken for... -
In Vivo Imaging of Naked and Microencapsulated Islet Cell Transplantation
We describe step-by-step methods to label human pancreatic islet cells and murine insulinoma cells and their subsequent transplantation into type I... -
Common Variants and Pitfalls: Paget’s Disease
Paget’s disease is a common disorder causing focal areas of increased and disorganized bone turnover. Its appearance on imaging can be mistaken for... -
Foot and Ankle Bone SPECT/CT Acquisition Protocol
Over the last two decades, bone SPECT/CT has become the backbone of skeletal imaging in nuclear medicine. Combining the superb sensitivity of... -
Foot and Ankle Bone SPECT/CT Acquisition Protocol
Over the last two decades, bone SPECT/CT has become the backbone of skeletal imaging in nuclear medicine. Combining the superb sensitivity of... -
Uncertainty Analysis of Time-Integrated Activity Coefficient in Single-Time-Point Dosimetry Using Bayesian Fitting Method
PurposeCalculation of the uncertainty of the individual time-integrated activity coefficient (TIACs) is desirable in molecular radiotherapy. However,...
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Prediction of [177Lu]Lu-DOTA-TATE therapy response using the absorbed dose estimated from [177Lu]Lu-DOTA-TATE SPECT/CT in patients with metastatic neuroendocrine tumour
BackgroundPeptide receptor radionuclide therapy (PRRT) with [ 177 Lu]Lu-DOTA-TATE has shown efficacy in patients with metastatic neuroendocrine...
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