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Whole genome sequencing of families diagnosed with cardiac channelopathies reveals structural variants missed by whole exome sequencing
Cardiac channelopathies are a group of heritable disorders that affect the heart’s electrical activity due to genetic variations present in genes...
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Caveats for Watermelon Whole Genome Sequencing
Watermelon is a highly important vegetable crop species worldwide, with its abundance of genetic resources aiding in identifying mechanisms and...
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A pipeline for sample tagging of whole genome bisulfite sequencing data using genotypes of whole genome sequencing
BackgroundIn large-scale high-throughput sequencing projects and biobank construction, sample tagging is essential to prevent sample mix-ups. Despite...
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Analyzing somatic mutations by single-cell whole-genome sequencing
Somatic mutations are the cause of cancer and have been implicated in other, noncancerous diseases and aging. While clonally expanded mutations can...
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Whole genome sequencing in clinical practice
Whole genome sequencing (WGS) is becoming the preferred method for molecular genetic diagnosis of rare and unknown diseases and for identification of...
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Whole-genome sequencing in medicinal plants: current progress and prospect
Advancements in genomics have dramatically accelerated the research on medicinal plants, and the development of herbgenomics has promoted the...
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A cost-effective sequencing method for genetic studies combining high-depth whole exome and low-depth whole genome
Whole genome sequencing (WGS) at high-depth (30X) allows the accurate discovery of variants in the coding and non-coding DNA regions and helps...
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Construction of high coverage whole-genome sequencing libraries from single colon crypts without DNA extraction or whole-genome amplification
ObjectiveComprehensive and reliable genome-wide variant analysis of a small number of cells has been challenging due to genome coverage bias, PCR...
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Targeted Whole Genome Sequencing of the Capripoxvirus Genome from Clinical Tissue Samples and Lyophilized Vaccine Batches
Diseases caused by Capripoxviruses (CaPVs) are of great economic importance in sheep, goats, and cattle. Since CaPV strains are serologically...
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Whole Genome Sequencing for Outbreak Investigation
The pairing of whole genome microbial sequencing with epidemiological data provides powerful, high-resolution data that can inform investigations...
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Bayesian cost-effectiveness analysis of Whole genome sequencing versus Whole exome sequencing in a pediatric population with suspected genetic disorders
Genetic diseases are medical conditions caused by sequence or structural changes in an individual’s genome. Whole exome sequencing (WES) and whole...
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Whole Genome Sequencing Applications in Hospital Epidemiology and Infection Prevention
Purpose of ReviewWhole genome sequencing is increasingly used in epidemiologic surveillance in healthcare centers, shedding new light on the...
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Whole Genome Sequencing for Food Safety, Clinical and Public Health Microbiology
Whole genome sequencing (WGS) has become the new technological standard in public health surveillance and disease control systems worldwide. WGS...
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What Whole Genome Sequencing Has Told Us About Pathogenic Vibrios
When the first microbial genome sequences were published just 20 years ago, our understanding regarding the microbial world changed dramatically. The...
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Novel ITPA variants identified by whole genome sequencing and RNA sequencing
Approximately 80% of rare diseases have a genetic cause, and an accurate genetic diagnosis is necessary for disease management, prognosis prediction,...
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Optimized whole-genome sequencing workflow for tumor diagnostics in routine pathology practice
Two decades after the genomics revolution, oncology is rapidly transforming into a genome-driven discipline, yet routine cancer diagnostics is still...
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Universal whole-genome Oxford nanopore sequencing of SARS-CoV-2 using tiled amplicons
We developed a comprehensive multiplexed set of primers adapted for the Oxford Nanopore Rapid Barcoding library kit that allows universal SARS-CoV-2...
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Data of whole-genome sequencing of Karakul, Zel, and Kermani sheep breeds
ObjectiveThe data provided herein represent the whole-genome sequencing data associated with three sheep breeds of Iranian native breeds. Sheep are...
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Use of Whole Genome Sequencing for Mycobacterium tuberculosis Complex Antimicrobial Susceptibility Testing
Whole genome sequencing (WGS) is becoming an important diagnostic tool for antimicrobial susceptibility testing of Mycobacterium tuberculosis complex...
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Mosaic chromosomal alterations in blood across ancestries using whole-genome sequencing
Megabase-scale mosaic chromosomal alterations (mCAs) in blood are prognostic markers for a host of human diseases. Here, to gain a better...
