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Synthesis of 5-oxo-1-(5-R-1,3,4-thiadiazol-2-yl)pyrrolidine-3-carboxylic acids
A series of new heterocyclic ensembles, derivatives of 5-oxo-1-(1,3,4-thiadiazol-2-yl)-pyrrolidine-3-carboxylic acid, was synthesized by heating...
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Catalytic enantioselective reductive alkynylation of amides enables one-pot syntheses of pyrrolidine, piperidine and indolizidine alkaloids
The primary objective in synthetic organic chemistry is to develop highly efficient, selective, and versatile synthetic methodologies, which are...
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Mutagenetic analysis of the biosynthetic pathway of tetramate bripiodionen bearing 3-(2H-pyran-2-ylidene)pyrrolidine-2,4-dione skeleton
BackgroundNatural tetramates are a family of hybrid polyketides bearing tetramic acid (pyrrolidine-2,4-dione) moiety exhibiting a broad range of...
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Design, synthesis, molecular docking and biological studies of some novel pyrrolidine-triazole-aurone hybrids against digestive enzymes
Here in this work we successfully designed and synthesized a library of some novel pyrrolidine-triazole-aurone hybrids i.e. ( Z )-2-benzylidene-6-((1-(2-(pyrrolidin-1-yl)ethyl)-1...
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Sterically shielded pyrrolidine nitroxides with 3-(4,5-dicarboxy-1H-1,2,3-triazol-1-yl)propyl substituent
Water-soluble spin probes were obtained from reduction-resistant sterically shielded pyrrolidine nitroxides by forming a 4,5-dicarboxy-1 H -1,2,3-triazo...
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Recent advances in the chemistry of pyrrolidine-2,3-diones (microreview)
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An efficient one-pot synthesis and docking studies of bioactive new antiproliferative dispiro[oxindole/acenaphthylenone‒benzofuranone] pyrrolidine scaffolds
A new and efficient method has been developed to synthesize dispiro[oxindole/acenaphthylenone-benzofuranone]pyrrolidine compounds. This is done by...
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Therapeutic potential of pyrrole and pyrrolidine analogs: an update
The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has been a versatile field of study for a long time for its...
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The possible protective effect of the nuclear factor kappa B inhibitor pyrrolidine dithiocarbamate on tramadol-induced testicular damage in rats
BackgroundTramadol provokes oxidative stress that gives rise to apoptosis with alterations in the cellular structure and adversely influences male...
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Synthesis of 3-spiro-annulated pyrrolidine-2-thiones (microreview)
In this microreview we provide general information on synthetic methods published over the previous 10 years providing access to a promising group of...
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Synthesis, Structure, Hirshfeld Surface Analysis, Non-Covalent Interaction, and In Silico Studies of 4-Hydroxy-1-[(4-Nitrophenyl)Sulfonyl]Pyrrolidine-2-Carboxyllic Acid
The new compound 4-hydroxy-1-[(4-nitrophenyl)sulfonyl]pyrrolidine-2-carboxyllic acid was obtained by the reaction of 4-hydroxyproline with...
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Spectral Studies of Coordination of 1-Methyl-2-(pyridin-4-yl)-3,4-fullero[60]pyrrolidine by Highly Substituted Cobalt(II) Porphyrin
AbstractA new dendrimeric cobalt(II) complex CoP has been obtained when reacting (5,15-bis[3,5-bis( tert -butyl)phenyl]-10,20-bis{4,6-bis[3,5-bis(3,6-di-...
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Novel pyrrolidine-aminophenyl-1,4-naphthoquinones: structure-related mechanisms of leukemia cell death
Novel derivatives of aminophenyl-1,4-naphthoquinones, in which a pyrrolidine group was added to the naphthoquinone ring, were synthesized and...
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DFT Study of Adsorption of Methyl Red on the Surface of Pure, Pyrrolidine-Functionalized, Silicon- and Germanium-Doped Zigzag (6, 0) Carbon Nanotubes
AbstractIn the present study, the adsorption of methyl red on the surface of pure zigzag (6, 0) carbon nanotube was investigated using the density...
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Synthesis of Pyrrolidine-2,3-dione Derivatives by Reacting Methyl 4-(4-Fluorophenyl)-2,4-dioxobutanoate with Tryptamine and Aromatic Aldehydes
AbstractShort-term heating of a mixture of tryptamine, aromatic aldehyde, and methyl 4-(4-fluorophenyl)-2,4-dioxobutanoate, followed by kee** for a...
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Synthesis, Chemical Structure, and Ground- and Excited-State Spectral Characteristics of (Porphyrinato)(chloro)indium(III) and Its Complexes with C60 and Pyridyl-Substituted Fullero[60]pyrrolidine
AbstractNew complexes of [5,10,15,20-tetra-(4-methoxyphenyl)porphinato](chloro)indium(III) ((Cl)InTPP( p -OCH 3 ) 4 ) with unsubstituted C 60 and...
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Design, synthesis and antifungal activity of novel amide derivatives containing a pyrrolidine moiety as potential succinate dehydrogenase inhibitors
To discover new succinate dehydrogenase inhibitors (SDHI) fungicides, a series of amide derivatives containing a pyrrolidine moiety were designed and...
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Synthesis of 5-oxo-1-[4-(aminosulfonyl)phenyl]pyrrolidine-3-carboxylic acids
A series of new 1-[4-(aminosulfonyl)phenyl]-5-oxopyrrolidine-3-carboxylic acids were synthesized by the solvent-free condensation of...
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Pyrrolidine in Drug Discovery: A Versatile Scaffold for Novel Biologically Active Compounds
The five-membered pyrrolidine ring is one of the nitrogen heterocycles used widely by medicinal chemists to obtain compounds for the treatment of...
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Formation Kinetics, Structure, and Spectral Properties of Oxo[5,10,15,20-tetra(4-methylphenyl)porphinato](ethoxy)molybdenum(V) Complexes with 4-Picoline and N-Methyl-2-(pyridin-4-yl)-3,4-fullero[60]pyrrolidine
AbstractStudying the axial chemistry of metalloporphyrins enables the transition to supramolecular structures, including nanoscale ones, for...
