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Quantification of Protein Palmitoylation by Cysteine-SILAC
Cysteine-SILAC enables the detection and quantification of protein S-palmitoylation, an important protein posttranslational modification. Here we...
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Palmitoylation landscapes across human cancers reveal a role of palmitoylation in tumorigenesis
BackgroundProtein palmitoylation, which is catalyzed by palmitoyl-transferase and de-palmitoyl-transferase, plays a crucial role in various...
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Palmitoyltransferase DHHC9 and acyl protein thioesterase APT1 modulate renal fibrosis through regulating β-catenin palmitoylation
palmitoylation, a reversible post-translational modification, is initiated by the DHHC family of palmitoyltransferases and reversed by several acyl...
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Global profiling of protein S-palmitoylation in the second-generation merozoites of Eimeria tenella
The intracellular protozoan Eimeria tenella is responsible for avian coccidiosis which is characterized by host intestinal damage. During...
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Palmitoylation of vacuole membrane protein 1 promotes small extracellular vesicle secretion via interaction with ALIX and influences intercellular communication
BackgroundSmall extracellular vesicles (EVs), exemplified by exosomes, mediate intercellular communication by transporting proteins, mRNAs, and...
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Prediction of S-Palmitoylation Sites in the Male/Female Mouse Using the Protein Language Model
S-palmitoylation, i.e. post-translational modification of cysteine thiol side chain, is crucial in various biological processes and human diseases....
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Current knowledge of protein palmitoylation in gliomas
Malignant tumor cells can obtain proliferative benefits from deviant metabolic networks. Emerging evidence suggests that lipid metabolism are...
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Flotillin-1 palmitoylation is essential for its stability and subsequent tumor promoting capabilities
Flotillin-1 contributes to invasion and metastasis in triple negative breast cancer (TNBC) and is modified post-translationally through...
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Estrogen Regulates Scribble Localization in Endometrial Epithelial Cells Through Acyl Protein Thioesterase (APT)-Mediated S-Palmitoylation in Adenomyosis
Despite its prevalence and the severity of symptoms, little is known about the pathogenesis and etiology of adenomyosis. In our previous study,...
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Regulation of RAS palmitoyltransferases by accessory proteins and palmitoylation
Palmitoylation of cysteine residues at the C-terminal hypervariable regions in human HRAS and NRAS, which is necessary for RAS signaling, is...
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zDHHC20-driven S-palmitoylation of CD80 is required for its costimulatory function
CD80 is a transmembrane glycoprotein belonging to the B7 family, which has emerged as a crucial molecule in T cell modulation via the CD28 or CTLA4...
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A palmitoylation–depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis
Gasdermin D (GSDMD) is the executor of pyroptosis, which is important for host defence against pathogen infection. Following activation,...
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Regulation of Cell Polarity by Posttranslational Protein Palmitoylation
Cell polarity is a common feature of many living cells, especially epithelial cells, and plays important roles in development, tissue homeostasis,...
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Palmitoylation-driven PHF2 ubiquitination remodels lipid metabolism through the SREBP1c axis in hepatocellular carcinoma
Palmitic acid (PA) is the most common fatty acid in humans and mediates palmitoylation through its conversion into palmitoyl coenzyme A. Although...
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Limb-Clas** Response in NMDA Receptor Palmitoylation-Deficient Mice
Proper regulation of N -methyl- d -aspartate-type glutamate receptor (NMDA receptor) expression is responsible for excitatory synaptic functions in the...
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Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice
Toll-like receptor 9 (TLR9) recognizes self-DNA and plays intricate roles in systemic lupus erythematosus (SLE). However, the molecular mechanism...
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ZDHHC20-mediated S-palmitoylation of YTHDF3 stabilizes MYC mRNA to promote pancreatic cancer progression
Post-translational modifications of proteins in malignant transformation and tumor maintenance of pancreatic ductal adenocarcinoma (PDAC) in the...
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Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging
Autophagy is a lysosome-dependent degradation pathway essential for cellular homeostasis, which decreases with age. However, it is unclear how aging...
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ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane localization and epithelial-mesenchymal transition in glioma
BackgroundAbnormal activation of FAK is associated with tumor development and metastasis. Through interactions with other intracellular signalling...
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Inhibition of acetyl-CoA carboxylase impaired tubulin palmitoylation and induced spindle abnormalities
Tubulin s-palmitoylation involves the thioesterification of a cysteine residue in tubulin with palmitate. The palmitate moiety is produced by the...
